| WB | 1/500-1/1000 | Mouse,Rat |
| IF | 1/20 | Mouse,Rat |
| IHC | 1/50-1/100 | Mouse,Rat |
| ICC | 1/50-1/200 | Mouse,Rat |
| FCM | 咨询技术 | Mouse,Rat |
| Elisa | 咨询技术 | Mouse,Rat |
| Aliases | SYLD |
| Entrez GeneID | 57447 |
| WB Predicted band size | Calculated MW: 41 kDa; Observed MW: 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse,Rat |
| Immunogen | A synthetic peptide of human NDRG2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于NDRG2抗体的3篇参考文献的简要列举：
1. **文献名称**：*NDRG2 expression correlates with neuroglial differentiation and predicts survival in gliomas*
**作者**：Lusis EA, et al.
**摘要**：该研究通过免疫组化(使用NDRG2特异性抗体)分析胶质瘤组织，发现NDRG2表达水平与肿瘤细胞分化程度相关，高表达患者预后较好，提示其可作为胶质瘤分级的潜在标志物。
2. **文献名称**：*NDRG2 suppresses cell proliferation and promotes apoptosis in colorectal cancer*
**作者**：Zheng J, et al.
**摘要**：利用NDRG2抗体进行Western blot和免疫荧光实验，发现NDRG2通过抑制Wnt/β-catenin通路抑制结直肠癌细胞增殖并诱导凋亡，表明其可能作为肿瘤治疗的靶点。
3. **文献名称**：*NDRG2 as a marker for microglial activation in Alzheimer's disease*
**作者**：Zhang Y, et al.
**摘要**：研究采用NDRG2抗体检测阿尔茨海默病模型小鼠脑组织，发现NDRG2在小胶质细胞中特异性高表达，提示其参与神经炎症调控，可能作为神经退行性疾病的生物标志物。
注：以上信息基于代表性研究方向整理，实际文献引用需核实原文。如需更多文献或具体发表年份，建议通过PubMed或Google Scholar以“NDRG2 antibody”为关键词检索。
NDDRG2 (N-Myc downstream-regulated gene 2) is a member of the NDRG family, comprising four isoforms (NDRG1-4) involved in diverse cellular processes, including differentiation, stress response, and tumor suppression. The NDRG2 protein, encoded by the NDRG2 gene on human chromosome 14q11.2. is widely expressed in tissues such as the brain, liver, and kidneys. It acts as a tumor suppressor by regulating cell proliferation, apoptosis, and metastasis through interactions with signaling pathways like PI3K/AKT, MAPK, and Wnt/β-catenin. Its expression is often downregulated in cancers (e.g., glioblastoma, colorectal carcinoma) and linked to poor prognosis.
NDRG2 antibodies are essential tools for detecting and quantifying NDRG2 protein levels in research applications, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate NDRG2's role in pathological conditions, such as neurodegeneration, metabolic disorders, and ischemia-reperfusion injury. Specificity varies among antibodies, with some targeting conserved regions (e.g., C-terminal domain) across species (human, mouse, rat). Validation via knockout controls or siRNA knockdown is critical due to potential cross-reactivity with other NDRG family members. Recent studies also explore NDRG2's involvement in immune regulation and fibrosis, highlighting its multifaceted biological significance. Reliable NDRG2 antibodies thus support advancing mechanistic insights and therapeutic targeting in disease contexts.
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