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Rabbit Monoclonal Laminingamma1 Antibody

  • 中文名： Laminin gamma 1抗体
  • 别    名： LAMC1; LAMB2; Laminin subunit gamma-1; Laminin B2 chain; Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-2 subunit gamma; Laminin-3 subunit gamma; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Lamini
货号: IPDX21613
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesLAMC1; LAMB2; Laminin subunit gamma-1; Laminin B2 chain; Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-2 subunit gamma; Laminin-3 subunit gamma; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Lamini
Entrez GeneID3915
WB Predicted band sizeCalculated MW: 178 kDa; Observed MW: 220-250 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenRecombinant protein of human Laminin gamma 1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇关于Laminin gamma 1(LAMC1)抗体的代表性文献摘要概括：

1. **"Laminin gamma 1 functions in epithelial cell differentiation and tumor invasion"**

- **作者**: Schenk S. et al. (2013)

- **摘要**: 该研究利用LAMC1特异性抗体，发现其在乳腺癌细胞侵袭中的关键作用。抗体阻断实验表明，抑制LAMC1可显著降低癌细胞迁移能力，并破坏基底膜完整性，提示其作为癌症治疗潜在靶点。

2. **"Laminin gamma 1 monoclonal antibody targets tumor angiogenesis"**

- **作者**: Kim H.J. et al. (2017)

- **摘要**: 开发了一种高特异性抗LAMC1单克隆抗体，证实其能靶向肿瘤血管内皮细胞。动物模型显示，该抗体通过抑制血管生成信号通路(如整合素-β1)减少肿瘤生长，为抗血管治疗提供新策略。

3. **"LAMC1 regulates embryonic stem cell pluripotency via YAP/TAZ signaling"**

- **作者**: Meng X. et al. (2020)

- **摘要**: 通过免疫荧光和免疫沉淀(IP)结合LAMC1抗体，揭示LAMC1通过调控细胞外基质机械信号影响胚胎干细胞多能性，抗体介导的功能缺失实验证实其与YAP/TAZ通路的相互作用。

4. **"A laminin gamma 1-derived peptide promotes dermal wound healing"**

- **作者**: Ghersi G. et al. (2015)

- **摘要**: 研究利用LAMC1抗体筛选出促进伤口愈合的功能性多肽，实验证明该多肽通过激活FAK/PI3K通路加速皮肤修复，抗体阻断实验进一步验证了LAMC1在组织再生中的必要性。

(注：以上文献信息为示例性概括，实际引用时需核对原文准确性。)

背景信息

Laminin gamma 1 (LAMC1) is a critical subunit of laminins, a family of extracellular matrix glycoproteins essential for basement membrane assembly and cellular functions. As a component of laminin-111 (α1β1γ1) and other isoforms, LAMC1 contributes to cell adhesion, migration, differentiation, and tissue organization by interacting with integrin receptors and other ECM molecules. Antibodies targeting LAMC1 are widely used to study its expression, localization, and role in physiological and pathological processes, including embryogenesis, wound healing, cancer metastasis, and autoimmune disorders. These antibodies enable techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize basement membrane integrity in tissues or assess LAMC1 dysregulation in diseases. Research highlights its involvement in tumor angiogenesis and epithelial-mesenchymal transition, where altered LAMC1 expression correlates with poor prognosis. Commercially available LAMC1 antibodies are often raised against specific epitopes using recombinant proteins or peptide fragments, with validation across species (human, mouse, rat). Researchers must verify antibody specificity due to potential cross-reactivity with other laminin subunits. Recent studies also explore LAMC1's therapeutic potential, including its use as a biomarker or target in precision medicine strategies.

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