| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CT32; LDH3; LDHX |
| Entrez GeneID | 3948 |
| WB Predicted band size | Calculated MW: 36 kDa; Observed MW: 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human Lactate Dehydrogenase C |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于 Lactate Dehydrogenase C(LDH-C)抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *"Immunogenicity and contraceptive potential of lactate dehydrogenase-C4"*
**作者**: Goldberg, E., et al.
**摘要**: 研究探讨了LDH-C4作为避孕疫苗靶点的潜力，通过动物实验证明其抗体可显著抑制精子活性，降低生育率，为免疫避孕提供了理论依据。
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2. **文献名称**: *"Expression of lactate dehydrogenase C in mammalian germ cells"*
**作者**: Odet, F., et al.
**摘要**: 通过免疫组化分析，发现LDH-C在小鼠、人类等多种哺乳动物睾丸和卵巢中特异性表达，提示其在生殖细胞能量代谢中的关键作用，抗体可用于生殖相关疾病研究。
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3. **文献名称**: *"LDH-C4 as a biomarker for ovarian cancer: Correlation with tumor progression"*
**作者**: Li, Y., et al.
**摘要**: 研究发现卵巢癌患者血清LDH-C水平升高，抗LDH-C抗体检测可辅助诊断及预后评估，表明其在癌症生物标志物开发中的应用潜力。
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(注：以上文献信息为示例性概括，实际引用需以具体文献内容为准。)
Lactate dehydrogenase C (LDH-C), also known as LDHx or LDH3. is a tissue-specific isoform of the lactate dehydrogenase enzyme family, primarily expressed in germ cells of the testes and mature spermatozoa. Unlike other LDH isoforms involved in glycolysis, LDH-C plays a specialized role in sperm energy metabolism and maturation. Its unique structure, encoded by the LDHC gene on chromosome 11. allows optimal function in the anaerobic environments of the male reproductive tract.
Anti-LDH-C antibodies are autoantibodies that target this isoform. They may arise due to immune dysregulation, often linked to conditions like autoimmune infertility or testicular injury. In males, these antibodies can impair sperm function by interfering with energy production, potentially leading to reduced motility or immunoinfertility. In females, anti-LDH-C antibodies have been associated with immune responses against sperm antigens, contributing to unexplained infertility.
Clinically, LDH-C antibodies are investigated as biomarkers for immune-related infertility. Research also explores their relevance in certain cancers, as some tumors aberrantly express LDH-C to support Warburg-effect metabolism. Emerging studies suggest diagnostic potential in testicular cancer and chemotherapy resistance monitoring. Additionally, LDH-C's immunogenicity has prompted investigations into contraceptive vaccines, though therapeutic applications remain experimental. Current detection methods include ELISA and immunoblotting, primarily in research settings.
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