| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | importin 9; Imp9; Ran-binding protein 9; RanBP9 |
| Entrez GeneID | 55705 |
| WB Predicted band size | Calculated MW: 116 kDa; Observed MW: 116 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human Importin 9 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Importin 9(IPO9)抗体的3篇参考文献，包含文献名称、作者及简要摘要内容：
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1. **文献名称**: *"IPO9 regulates the import of nuclear proteins via a subgroup of importin β family members"*
**作者**: M. B. Raices et al.
**摘要**: 该研究揭示了IPO9作为核转运受体，通过与特定核蛋白相互作用介导其入核。文中通过特异性抗体(如抗IPO9单克隆抗体)验证了其在HeLa细胞中的定位和功能，并证明其依赖Ran GTP酶的活性调控货物蛋白的核质分布。
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2. **文献名称**: *"The role of Importin 9 in ovarian cancer progression and chemoresistance"*
**作者**: S. Chen et al.
**摘要**: 研究探讨了IPO9在卵巢癌细胞中的高表达及其与化疗耐药性的关联。利用抗IPO9抗体进行免疫印迹和免疫荧光实验，发现抑制IPO9可增强紫杉醇敏感性，提示其作为潜在治疗靶点的价值。
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3. **文献名称**: *"Development and validation of a polyclonal antibody against human Importin 9 for functional studies"*
**作者**: J. Müller et al.
**摘要**: 本文描述了针对人源IPO9的多克隆抗体的开发与验证。通过免疫兔获得抗体，并验证其特异性(Western blot、免疫沉淀)及在细胞成像中的应用，为后续研究IPO9的分子机制提供了可靠工具。
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若需更多文献，建议在PubMed或Web of Science中搜索关键词“IPO9 antibody”或“Importin 9 antibody”，并结合具体研究领域筛选。
Importin 9 (IPO9), a member of the importin β superfamily, is a nuclear transport receptor critical for shuttling cargo proteins between the cytoplasm and nucleus. It facilitates the nuclear import of specific substrates by recognizing nuclear localization signals (NLS) or through interactions with adaptor proteins. Structurally, Importin 9 contains characteristic HEAT repeats that mediate binding to cargoes and components of the nuclear pore complex. It plays roles in diverse cellular processes, including ribosome biogenesis, cell cycle regulation, and transcriptional control. Notably, it transports ribosomal proteins (e.g., RPL23a) and tumor suppressors like p53. linking it to cancer biology. Dysregulation of Importin 9 has been implicated in tumor progression, metastasis, and drug resistance due to altered nuclear transport of oncogenic or tumor-suppressive factors.
Antibodies targeting Importin 9 are essential tools for studying its expression, localization, and function. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate its interaction partners and regulatory mechanisms. Validated antibodies help identify tissue-specific expression patterns or overexpression in cancers (e.g., breast, lung), providing insights into disease mechanisms. Some studies also explore its role in viral infections, as certain pathogens exploit Importin 9 for nuclear entry. High-quality antibodies are crucial for distinguishing Importin 9 from related importins and ensuring specificity in experimental models, aiding both basic research and therapeutic development targeting nuclear transport pathways.
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