首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal NDRG3 Antibody

  • 中文名: NDRG3抗体
  • 别    名: NDRG3; Protein Ndr3; Protein NDRG3;;NDRG3
货号: IPDX18940
Price: ¥1280
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNDRG3; Protein Ndr3; Protein NDRG3;;NDRG3
WB Predicted band sizeCalculated MW: 41 kDa ; Observed MW: 45 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human NDRG3
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

+ +

参考文献

以下是关于NDRG3抗体的3篇参考文献,包含文献名称、作者及简要摘要内容:

---

1. **"NDRG3 is a novel hypoxia-inducible protein that promotes cancer cell adaptation to hypoxia by regulating mTOR signaling"**

*Author: Lee J, et al.*

摘要:本研究揭示NDRG3在缺氧肿瘤微环境中的调控机制,通过特异性抗体检测其在多种癌细胞中的表达,发现其通过mTOR通路促进肿瘤细胞代谢适应,抗体应用于Western blot和免疫荧光验证定位。

---

2. **"Characterization of NDRG3 in prostate cancer progression and its role in androgen receptor signaling"**

*Author: Liu Y, et al.*

摘要:利用NDRG3特异性抗体分析前列腺癌组织样本,发现NDRG3表达与肿瘤侵袭性相关,并通过免疫组化证实其作为潜在预后标志物的价值,研究还探讨其与雄激素受体通路的相互作用。

---

3. **"NDRG3 modulates AMPK pathway to regulate cellular energy homeostasis"**

*Author: Zhang H, et al.*

摘要:通过shRNA敲低和NDRG3抗体功能验证实验,证明NDRG3通过AMPK调控细胞能量代谢,抗体用于检测敲除效率及组织分布,为代谢性疾病治疗提供新靶点。

---

*注:以上文献为示例,实际引用需核对具体来源及发表信息。如需准确文献,建议通过PubMed或Google Scholar以“NDRG3 antibody”为关键词检索。*

背景信息

The NDRG3 (N-Myc downstream-regulated gene 3) antibody is a tool used to study the protein encoded by the NDRG3 gene, a member of the NDRG family involved in cellular processes like differentiation, stress response, and cancer progression. NDRG3 is hypoxia-inducible via HIF-1α and has been linked to tumor microenvironments, where it may regulate metabolic adaptation and angiogenesis. Its expression varies across tissues, with higher levels observed in the prostate, testis, and liver. Research highlights its dual role in cancer: while it promotes progression in some malignancies (e.g., prostate cancer) by enhancing cell proliferation and survival through RAS/RAF signaling, it acts as a tumor suppressor in others (e.g., liver cancer) by modulating stress-related pathways. The antibody enables detection of NDRG3 in techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding studies on its localization and expression dynamics. Commercially available NDRG3 antibodies vary in host species (rabbit, mouse), clonality (monoclonal/polyclonal), and applications, requiring validation for specificity. Ongoing research focuses on clarifying its context-dependent roles in cancer and hypoxia, with potential implications for therapeutic targeting.

客户数据及评论

折叠内容

大包装询价

×