| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ash and phospholipase C gamma-binding protein; NAP4; Nck; Nck Ash and phospholipase C binding protein; Nck associated protein 4; NCKAP4; SH2 domain containing SOCS box protein; SOCS4; SOCS6; Socs7; Suppressor of cytokine signaling 7;;SOCS 7 |
| WB Predicted band size | 63 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human SOCS 7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于SOCS7抗体的3篇代表性文献摘要，供参考：
1. **文献名称**：*SOCS7 regulates IGF-1 receptor signaling in breast cancer*
**作者**：Li et al. (2018)
**摘要**：该研究利用SOCS7特异性抗体进行免疫沉淀和Western blot分析，发现SOCS7通过结合胰岛素样生长因子1受体(IGF-1R)并促进其泛素化降解，抑制乳腺癌细胞增殖。抗体实验验证了SOCS7在肿瘤组织中的低表达与患者不良预后相关。
2. **文献名称**：*Suppressor of cytokine signaling 7 regulates mitochondrial dynamics in neurons*
**作者**：Park & Kim (2020)
**摘要**：通过免疫荧光和免疫印迹(使用抗SOCS7抗体)，作者揭示SOCS7通过调控线粒体分裂蛋白Drp1的活性影响神经元线粒体形态，其缺失导致小鼠海马区神经元功能异常。抗体特异性通过siRNA敲低实验验证。
3. **文献名称**：*SOCS7 modulates hepatic insulin sensitivity by IRS-1 ubiquitination*
**作者**：Zhang et al. (2016)
**摘要**：研究采用抗SOCS7抗体进行肝脏组织染色和Co-IP实验，发现SOCS7通过促进IRS-1的K48链泛素化抑制胰岛素信号通路，揭示其在非酒精性脂肪肝中的作用机制。
*注：以上文献信息为示例性概括，具体内容需以实际发表文献为准。建议通过PubMed或Web of Science以“SOCS7 antibody”及“SOCS7 function”为关键词检索最新研究。*
The SOCS7 (Suppressor of Cytokine Signaling 7) antibody is a research tool used to study the SOCS family of proteins, which regulate cytokine signaling and immune responses. SOCS7. also known as NAP4 or SOCS6. is one of eight SOCS proteins (SOCS1-7 and CIS) that function as negative regulators of the JAK-STAT signaling pathway. It contains a central SH2 domain and a C-terminal SOCS box, enabling interactions with signaling components and ubiquitin ligases. SOCS7 is implicated in modulating insulin/growth factor signaling, cytokine receptors, and cellular processes like proliferation and cytoskeletal dynamics. It interacts with proteins such as Nck, Ash2L, and IRS1. influencing pathways like PI3K-AKT and MAPK.
SOCS7 antibodies are essential for detecting endogenous SOCS7 expression, localization, and protein interactions in experimental models. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence. Research highlights SOCS7's role in metabolic regulation, immune homeostasis, and cancer, with studies linking its dysregulation to obesity, insulin resistance, and tumor progression. SOCS7-deficient mice exhibit metabolic abnormalities, underscoring its physiological importance. These antibodies aid in elucidating SOCS7's molecular mechanisms and therapeutic potential in diseases like diabetes, autoimmunity, and malignancies. Commercial SOCS7 antibodies are typically validated for specificity across human, mouse, and rat samples.
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