| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ELP4; hELP4; PAX6NEB; PAXNEB;;Elongator complex protein 4 |
| WB Predicted band size | Calculated MW: 47 kDa ; Observed MW: 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human Elongator complex protein 4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于ELP4抗体的模拟参考文献示例(请注意，这些文献为虚构示例，实际文献需通过学术数据库检索获取)：
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1. **文献名称**: *ELP4 Expression and Its Role in Neuronal Development*
**作者**: Smith A, et al.
**摘要**: 本研究通过ELP4抗体进行免疫印迹和免疫组化实验，发现ELP4蛋白在小鼠海马体发育过程中高表达，提示其可能通过调控Elongator复合体活性影响神经元分化。
2. **文献名称**: *Association of ELP4 Variants with Childhood Epilepsy: A Proteomic Approach*
**作者**: Chen L, et al.
**摘要**: 研究利用ELP4抗体检测患者脑脊液样本，发现ELP4表达水平与特定癫痫表型相关，支持ELP4基因多态性通过蛋白质功能异常导致疾病风险的假说。
3. **文献名称**: *ELP4 Antibody Characterization in Cancer Cell Models*
**作者**: García R, et al.
**摘要**: 该文献报道了一种新型ELP4抗体的开发与验证，通过免疫沉淀和质谱分析证实其在神经母细胞瘤细胞系中特异性识别ELP4.并揭示其与肿瘤迁移的潜在关联。
4. **文献名称**: *Elongator Complex Subunit ELP4 Regulates Autophagy via Histone Acetylation*
**作者**: Wang X, et al.
**摘要**: 使用ELP4抗体进行ChIP-seq分析，发现ELP4通过调控靶基因启动子区域的组蛋白乙酰化水平影响自噬通路，为神经退行性疾病机制提供新见解。
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建议通过 **PubMed**、**Web of Science** 或 **Google Scholar** 搜索关键词“ELP4 antibody”、“ELP4 protein function”或结合具体研究领域(如神经科学、癌症)获取真实文献。
The ELP4 antibody is designed to detect Elongator Complex Protein 4 (ELP4), a critical subunit of the multi-functional Elongator complex. This highly conserved complex, composed of six subunits (ELP1-ELP6), plays diverse roles in transcriptional regulation, tRNA modification, and cytoskeletal dynamics. ELP4. along with ELP5 and ELP6. forms a subcomplex essential for stabilizing the holoenzyme and enabling its acetyltransferase activity. Studies link ELP4 to neurodevelopment, as its dysfunction is associated with disorders like Rolandic epilepsy, speech apraxia, and autism spectrum disorders. Variations in the ELP4 gene may influence cortical connectivity and neuronal migration during brain development.
ELP4 antibodies are primarily used in research to investigate the protein's expression patterns, molecular interactions, and role in disease mechanisms. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Such studies have revealed ELP4's tissue-specific expression, particularly in the brain, and its involvement in processes like α-tubulin acetylation and mRNA processing. Commercially available antibodies are typically validated for specificity using knockout controls, though functional variations between batches require careful optimization. Current research focuses on elucidating how ELP4 mutations contribute to neurological phenotypes and exploring therapeutic strategies targeting Elongator complex activity.
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