| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MC2; MC5R; Melanocortin 5 receptor;;MC5R |
| WB Predicted band size | Calculated MW: 37 kDa ; Observed MW: 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human MC5R |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于MC5受体(MC5R)抗体的模拟参考文献示例(内容为虚构，仅供格式参考)：
1. **《MC5受体在皮脂腺中的功能表征与抗体开发》**
- 作者：Smith A, et al.
- 摘要：研究通过开发高特异性MC5R多克隆抗体，发现MC5R在小鼠皮脂腺中高表达，并通过抗体阻断实验证明其参与脂类代谢调控，可能成为治疗痤疮的靶点。
2. **《MC5受体抗体在免疫调节研究中的应用》**
- 作者：Zhang L, et al.
- 摘要：利用单克隆MC5R抗体检测免疫细胞表面受体分布，发现MC5R在巨噬细胞中激活抗炎信号通路，提示其在炎症性疾病中的潜在作用。
3. **《MC5R抗体揭示其在能量稳态中的新功能》**
- 作者：Johnson R, et al.
- 摘要：通过抗体免疫组化技术，研究揭示了MC5R在下丘脑神经元中的表达模式，并证实其通过AMPK通路影响能量消耗和体重调节。
4. **《人源MC5受体结构解析及抗体表位定位》**
- 作者：Wang Y, et al.
- 摘要：结合冷冻电镜技术和抗体验证，首次解析了MC5R的三维结构，并确定了抗体结合的关键表位区域，为药物设计提供结构基础。
**注意**：以上文献信息为模拟生成，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。建议使用关键词“MC5R antibody”或“Melanocortin 5 Receptor”查找真实研究。
The melanocortin-5 receptor (MC5R) is a member of the melanocortin receptor family, a group of G protein-coupled receptors (GPCRs) activated by melanocyte-stimulating hormones (α-MSH, β-MSH, γ-MSH) and adrenocorticotropic hormone (ACTH). MC5R is widely expressed in peripheral tissues, including exocrine glands, adipose tissue, immune cells, and skin, where it regulates diverse physiological processes such as sebum production, thermogenesis, and inflammation. Unlike other melanocortin receptors (e.g., MC1R in pigmentation or MC4R in appetite regulation), MC5R's role remains less defined but is implicated in energy homeostasis, immune modulation, and exocrine secretion.
Antibodies targeting MC5R are essential tools for studying its expression, localization, and signaling mechanisms. They enable detection of MC5R protein in tissues via techniques like immunohistochemistry, Western blotting, and flow cytometry. Research using MC5R antibodies has highlighted its involvement in pathological conditions, including metabolic disorders, skin diseases, and cancer. For example, MC5R activation in adipocytes influences lipolysis, while its role in sebaceous gland dysfunction links it to acne pathogenesis.
MC5R antibodies also aid in exploring ligand-receptor interactions and downstream pathways, such as cAMP signaling via adenylyl cyclase. Challenges include ensuring specificity due to structural homology among melanocortin receptors. Recent studies focus on developing therapeutic antibodies or antagonists for MC5R-related diseases, though clinical applications remain exploratory. Overall, MC5R antibodies are pivotal in unraveling the receptor's multifaceted biology and therapeutic potential.
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