| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HC3; PMSA2; Proteasome component C3; PSC2; PSC3; psmA2;;PSMA2 |
| WB Predicted band size | Calculated MW: 26 kDa ; Observed MW: 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human PSMA2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于PSMA2抗体的3篇参考文献示例(文献信息为虚构，仅供格式参考)：
1. **标题**：*PSMA2 as a novel biomarker in prostate cancer: Immunohistochemical analysis using a specific monoclonal antibody*
**作者**：Smith J, et al.
**摘要**：研究利用抗PSMA2单克隆抗体，通过免疫组化技术发现PSMA2在前列腺癌组织中高表达，并与肿瘤进展和患者预后不良相关。
2. **标题**：*Proteasome subunit α2 (PSMA2) antibody-based detection of oxidative stress in neurodegenerative models*
**作者**：Lee H, et al.
**摘要**：该研究通过Western blot和免疫荧光技术，使用抗PSMA2抗体证实了氧化应激条件下神经元中蛋白酶体活性下降与PSMA2表达异常的关系。
3. **标题**：*Autoantibody targeting PSMA2 in systemic lupus erythematosus: Diagnostic implications*
**作者**：Garcia R, et al.
**摘要**：研究发现系统性红斑狼疮(SLE)患者血清中存在针对PSMA2的自身抗体，提示其可能作为SLE的新型血清学标志物。
如需真实文献，建议通过PubMed或Google Scholar搜索关键词“PSMA2 antibody”或“Proteasome alpha 2 antibody”获取近期研究。
The PSMA2 (Proteasome Subunit Alpha 2) antibody is a tool used to detect the α2 subunit of the 20S proteasome, a core component of the ubiquitin-proteasome system responsible for intracellular protein degradation. PSMA2. encoded by the *PSMA2* gene, forms part of the catalytic chamber of the proteasome, playing a critical role in maintaining cellular homeostasis by regulating protein turnover. Dysregulation of proteasome activity is linked to various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions, making PSMA2 a research focus in these areas.
PSMA2 antibodies are widely employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study proteasome expression, localization, and function in different tissues or disease models. They are essential for investigating proteasome dynamics under stress, drug treatments, or genetic modifications. Commercially available antibodies are typically raised in rabbits or mice, validated for specificity through knockdown/knockout controls or peptide blocking assays.
Research using PSMA2 antibodies has contributed to understanding proteasome involvement in cancer progression, where elevated proteasome activity often correlates with tumor aggressiveness and drug resistance. Additionally, studies explore its role in neurodegenerative diseases like Alzheimer’s, characterized by abnormal protein aggregation. These antibodies also aid in evaluating proteasome inhibitors’ therapeutic efficacy, such as bortezomib in multiple myeloma. Overall, PSMA2 antibodies are vital for advancing both basic and translational research on protein homeostasis mechanisms.
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