| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BMP15; GDF9B; Growth/differentiation factor 9B; ODG2; POF4;;BMP15 |
| WB Predicted band size | Calculated MW: 45 kDa ; Observed MW: 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human BMP15 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于BMP15抗体的3篇代表性文献的简化示例(注：内容为模拟生成，实际文献需通过学术数据库查询)：
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1. **文献名称**: *"Production and characterization of a monoclonal antibody against human BMP15"*
**作者**: Vitt, U.A. et al.
**摘要**: 该研究报道了一种针对人源BMP15蛋白的单克隆抗体的开发与表征，验证了其在Western blot和免疫组化中的特异性，为研究BMP15在卵泡发育中的作用提供了工具。
2. **文献名称**: *"BMP15 antibody-based ELISA for ovarian reserve assessment"*
**作者**: Liao, W.X. et al.
**摘要**: 研究建立了一种基于BMP15抗体的ELISA检测方法，用于评估女性卵巢储备功能，发现血清BMP15水平与抗缪勒管激素(AMH)呈正相关，提示其潜在的临床诊断价值。
3. **文献名称**: *"BMP15 mutations and antibody-mediated functional analysis in premature ovarian failure"*
**作者**: Otsuka, F. et al.
**摘要**: 通过BMP15抗体阻断实验，探讨了BMP15基因突变导致卵巢早衰的分子机制，揭示了BMP15在颗粒细胞增殖和卵母细胞成熟中的关键调控作用。
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**备注**：以上文献信息为示例性质，实际引用需通过PubMed、Web of Science等平台检索真实文献。建议使用关键词“BMP15 antibody”“BMP15 immunoassay”或“BMP15 function”进行精确查询。
**Background of BMP15 Antibodies**
BMP15 (Bone Morphogenetic Protein 15), a member of the TGF-β superfamily, is an oocyte-secreted protein critical for ovarian folliculogenesis and female fertility. It regulates granulosa cell proliferation, hormone synthesis, and oocyte maturation, often synergizing with GDF9 (Growth Differentiation Factor 9). Dysregulation of BMP15 is linked to reproductive disorders, such as premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS).
BMP15 antibodies are tools designed to detect, quantify, or inhibit BMP15 in research and diagnostics. Polyclonal or monoclonal antibodies are used in techniques like Western blotting, immunohistochemistry (IHC), and ELISA to study BMP15 expression, localization, and interactions in ovarian tissues or cell models. Neutralizing antibodies may also explore therapeutic potential by modulating BMP15 activity in ovarian dysfunction.
Challenges include ensuring antibody specificity due to structural similarities among TGF-β family members. Validated BMP15 antibodies aid in elucidating its role in reproductive biology and developing diagnostics for infertility. Research continues to optimize antibody-based assays and therapeutic strategies targeting BMP15 pathways, emphasizing their relevance in advancing reproductive medicine.
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