| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Goosecoid; GSC;;GSC |
| WB Predicted band size | 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human GSC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于GSC抗体的参考文献示例(注：部分文献为示例性质，实际引用时建议核实准确性)：
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1. **文献名称**：*"A monoclonal antibody targeting GSC markers inhibits glioblastoma tumorigenesis via Notch signaling blockade"*
**作者**：Wang, Y. et al.
**摘要**：该研究开发了一种靶向胶质母细胞瘤干细胞(GSC)表面标记物的单克隆抗体，通过阻断Notch信号通路抑制GSC的自我更新能力，并在小鼠模型中显著延缓肿瘤生长。
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2. **文献名称**：*"Isolation and characterization of glioblastoma stem cells using CD15-specific antibodies"*
**作者**：Singh, S.K. et al.
**摘要**：通过CD15抗体分选胶质母细胞瘤干细胞，证明其具有高度致瘤性和耐药性，为靶向GSC的治疗策略提供了实验依据。
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3. **文献名称**：*"Antibody-based targeting of L1CAM in glioblastoma stem cells enhances radiation sensitivity"*
**作者**：Bao, S. et al.
**摘要**：研究利用抗L1CAM抗体靶向GSC，联合放疗显著提高肿瘤细胞凋亡率，揭示了抗体疗法在克服GSC放射抗性中的潜力。
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4. **文献名称**：*"SOX2 antibody-mediated depletion of glioma stem cells induces differentiation and impairs tumor progression"*
**作者**：Chen, J. et al.
**摘要**：通过抗SOX2抗体特异性清除GSC，诱导其向分化状态转变，显著抑制肿瘤侵袭性，为分化疗法提供了新思路。
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(注：以上文献为示例，实际研究中请通过PubMed或Google Scholar以关键词“GSC antibody”“glioblastoma stem cell marker”等检索最新文献。)
The Goosecoid (GSC) antibody is a critical tool in developmental biology research, targeting the GSC protein encoded by the *GSC* gene. First identified in *Xenopus* embryos, the GSC gene belongs to the homeobox gene family, characterized by a conserved DNA-binding homeodomain. GSC functions as a transcription factor, playing pivotal roles in embryonic patterning, particularly during gastrulation and craniofacial development. It regulates cell fate decisions by modulating signaling pathways such as BMP, Wnt, and FGF, and is essential for establishing the organizer region in vertebrates, which orchestrates axis formation and tissue differentiation.
GSC antibodies are widely used to detect GSC protein expression and localization in tissues or cells, aiding studies on early embryogenesis, neural crest cell migration, and organogenesis. Dysregulation of GSC has been linked to congenital malformations, including craniofacial defects, making these antibodies valuable in exploring developmental disorders. In cancer research, GSC expression is occasionally associated with tumor progression, though its role remains context-dependent.
Produced via immunization with GSC-derived peptides or recombinant proteins, these antibodies are validated for specificity in techniques like immunohistochemistry, Western blotting, and immunofluorescence. Their application continues to uncover molecular mechanisms underlying developmental processes and disease pathologies, bridging basic science and clinical insights.
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