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Rabbit Monoclonal IL15RA Antibody

  • 中文名： IL15RA抗体
  • 别    名： CD215; IL 15R alpha; IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; Il15ra; Interleukin 15 receptor alpha; sIL-15 receptor subunit alpha; sIL-15R-alpha; sIL-15RA ; Soluble interleukin 15 receptor subunit alpha;;IL 15 receptor alpha
货号: IPDX18660
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCD215; IL 15R alpha; IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; Il15ra; Interleukin 15 receptor alpha;  sIL-15 receptor subunit alpha; sIL-15R-alpha; sIL-15RA ; Soluble interleukin 15 receptor subunit alpha;;IL 15 receptor alpha
WB Predicted band sizeCalculated MW: 28 kDa ; Observed MW: 38 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human IL 15 receptor alpha
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇关于IL15RA抗体的代表性文献示例(注：内容为虚构模拟，仅供参考研究方向)：

1. **文献名称**：*Structural insights into IL-15Rα antibody-mediated receptor modulation*

**作者**：Smith A, et al.

**摘要**：该研究解析了IL15RA特异性抗体与受体结合的晶体结构，揭示了抗体通过阻断IL-15与受体α亚基的结合抑制下游信号传导，为开发靶向IL-15通路的治疗策略提供结构基础。

2. **文献名称**：*Anti-IL15RA antibody ameliorates autoimmune inflammation in murine models*

**作者**：Chen B, et al.

**摘要**：研究报道了一种人源化抗IL15RA抗体在类风湿性关节炎小鼠模型中的应用，证明其通过减少促炎细胞因子分泌和T细胞活化显著减轻关节炎症。

3. **文献名称**：*Targeting IL-15Rα enhances NK cell-mediated antitumor immunity*

**作者**：Wang C, et al.

**摘要**：该文献发现特定抗IL15RA抗体可通过稳定受体复合物延长IL-15的半衰期，从而增强自然杀伤细胞(NK)的肿瘤杀伤功能，提出其在癌症免疫治疗中的潜力。

4. **文献名称**：*IL-15Rα-specific antibody modulates dendritic cell homeostasis*

**作者**：Li X, et al.

**摘要**：研究探讨了抗IL15RA抗体对树突状细胞(DC)分化的调控作用，发现其通过干扰IL-15反式呈递信号通路影响DC的存活与免疫激活功能。

(注：以上文献及作者为模拟生成，实际引用请通过PubMed等学术平台检索验证。)

背景信息

The IL-15 receptor alpha (IL15RA) is a key subunit of the heterotrimeric IL-15 receptor complex, which also includes IL-2Rβ and the common gamma chain (γc). IL-15 signaling plays critical roles in immune regulation, particularly in the survival, proliferation, and activation of natural killer (NK) cells, CD8+ memory T cells, and innate lymphoid cells. IL15RA antibodies are designed to specifically target the IL-15Rα chain, modulating IL-15-mediated signaling pathways. These antibodies can act as antagonists to block IL-15/IL15RA interactions, potentially suppressing overactive immune responses in autoimmune diseases or inflammatory conditions. Alternatively, agonist antibodies may enhance IL-15 signaling to boost anti-tumor immunity in cancer immunotherapy. Research on IL15RA antibodies has expanded due to their therapeutic potential in diseases like rheumatoid arthritis, inflammatory bowel disease, and certain cancers. In preclinical studies, anti-IL15RA agents have shown efficacy in reducing inflammation and inhibiting pathological T-cell activation. Conversely, IL-15/IL15RA pathway activation is being explored to improve NK cell therapies or CAR-T cell persistence. As a research tool, IL15RA antibodies are widely used to study IL-15 biology, receptor distribution, and signaling mechanisms. Their development highlights the dual role of IL-15 in both promoting immune homeostasis and driving pathological inflammation, making IL15RA a nuanced therapeutic target. Clinical trials continue to evaluate their safety and efficacy profiles.

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