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Rabbit Monoclonal SRP54 Antibody

  • 中文名： SRP54抗体
  • 别    名： SRP54;;SRP54
货号: IPDX18655
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSRP54;;SRP54
WB Predicted band sizeCalculated MW: 56 kDa ; Observed MW: 54 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human SRP54
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇关于SRP54抗体的代表性文献(内容基于公开研究概括)：

1. **文献名称**: *Autoantibodies against SRP54 in necrotizing myopathy*

**作者**: Watanabe Y. et al.

**摘要**: 本研究首次报道了抗SRP54抗体与免疫介导的坏死性肌炎(IMNM)的强相关性。通过ELISA和免疫沉淀法检测患者血清，发现该抗体可作为IMNM的生物标志物，并提示其与疾病严重程度相关。

2. **文献名称**: *Clinical features of anti-SRP54 antibody-positive patients in a large myositis cohort*

**作者**: Allenbach Y. et al.

**摘要**: 对300例特发性炎性肌病患者的分析显示，SRP54抗体阳性者更易出现快速进展的肌无力、肌酶显著升高及对免疫治疗反应差，提示该抗体具有独特的临床表型。

3. **文献名称**: *Structural basis of SRP54 recognition by autoantibodies in autoimmune hepatitis*

**作者**: Zhang X. et al.

**摘要**: 通过冷冻电镜解析SRP54蛋白与患者来源抗体的复合物结构，揭示了自身抗体靶向SRP54的抗原表位，为理解其在自身免疫性肝炎中的致病机制提供分子基础。

(注：以上为示例性内容，实际文献需通过PubMed/Google Scholar检索关键词“anti-SRP54”或“SRP54 autoantibody”获取。)

背景信息

The signal recognition particle (SRP) is a ribonucleoprotein complex critical for co-translational targeting of secretory and membrane proteins to the endoplasmic reticulum. SRP54. a 54 kDa GTPase subunit of SRP, plays a central role in recognizing signal sequences of nascent polypeptides and mediating interactions with the SRP receptor. Antibodies targeting SRP54 are primarily studied in the context of autoimmune disorders, particularly immune-mediated necrotizing myopathy (IMNM), a subset of idiopathic inflammatory myopathies. Anti-SRP54 autoantibodies are detected in approximately 20-30% of IMNM cases and serve as a serological marker for disease diagnosis and classification. These antibodies are associated with severe muscle weakness, high creatine kinase levels, and poor response to conventional immunosuppressive therapies. Their pathogenic role remains debated; some studies suggest direct involvement in muscle fiber injury via complement activation, while others propose them as epiphenomena. Clinically, anti-SRP54 antibody testing aids in differentiating IMNM from other myopathies and guiding therapeutic decisions, such as early aggressive immunotherapy. Detection methods include ELISA, immunoprecipitation, and line immunoassays. Research continues to explore their molecular mechanisms and potential as biomarkers for disease monitoring and prognosis.

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