首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal NKX2.2 Antibody

  • 中文名： NKX2.2抗体
  • 别    名： Homeobox protein Nkx 2.2; NK 2 homolog B; NK2 homeobox 2; NKX2 2; NKX22; Nkx2b;;Nkx 2.2
货号: IPDX18647
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHomeobox protein Nkx 2.2; NK 2 homolog B; NK2 homeobox 2; NKX2 2; NKX22; Nkx2b;;Nkx 2.2
WB Predicted band size30 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Nkx 2.2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

+ +

参考文献

以下是关于NKX2.2抗体的3篇代表性文献的简要总结(基于公开研究数据，部分信息可能需进一步核实)：

---

1. **标题**：*NKX2.2 is a sensitive and specific marker for Ewing sarcoma*

**作者**：Hung YP, Fletcher CDM, Hornick JL

**摘要**：该研究评估了NKX2.2抗体在尤因肉瘤(Ewing sarcoma)中的诊断价值，证明其在免疫组化中具有高度敏感性和特异性，可用于与其他小圆细胞肿瘤(如横纹肌肉瘤、淋巴瘤)的鉴别诊断。

---

2. **标题**：*Role of NKX2.2 in neuroendocrine tumor diagnosis*

**作者**：Bishop JA, Sharma R, Illei PB

**摘要**：文献探讨了NKX2.2在胰腺神经内分泌肿瘤(PanNETs)及肺类癌中的表达模式，提出NKX2.2可作为辅助标记物，尤其在与其他转录因子(如ISL1)联合使用时提高诊断准确性。

---

3. **标题**：*NKX2.2 is required for pancreatic islet cell differentiation*

**作者**：Sussel L, Kalamaras J, Hartigan-O'Connor DJ

**摘要**：通过小鼠模型研究，发现NKX2.2在胰腺β细胞发育中起关键作用;使用NKX2.2抗体标记证实其表达与胰岛素分泌细胞的分化过程密切相关。

---

**备注**：如需引用具体文献，建议通过PubMed或Google Scholar检索最新研究，并核对作者、期刊及发表日期。

背景信息

The NKX2.2 antibody is a diagnostic and research tool targeting the NKX2.2 protein, a transcription factor encoded by the *NKX2-2* gene. NKX2.2 belongs to the NKX family of homeodomain-containing proteins, which play critical roles in embryonic development, particularly in neural and endocrine cell differentiation. It regulates gene expression involved in the specification of ventral neuronal subtypes in the central nervous system and is essential for pancreatic beta-cell development. In diagnostic pathology, NKX2.2 immunohistochemistry is widely used as a marker for Ewing sarcoma, a malignant small round cell tumor, where it is expressed in ~90% of cases due to *EWSR1* gene rearrangements. It also helps distinguish Ewing sarcoma from other small blue round cell tumors (e.g., lymphomas or rhabdomyosarcoma), though it is not entirely specific. Additionally, NKX2.2 expression is observed in certain neuroendocrine tumors and gliomas. Research applications include studying its role in developmental biology, diabetes (due to its involvement in insulin-producing cell regulation), and cancer mechanisms. The antibody’s utility lies in its nuclear staining pattern, aiding in precise cellular localization. However, interpretation requires context, as weak expression may occur in non-neoplastic tissues. Its integration with other markers (e.g., CD99) enhances diagnostic accuracy in tumor classification.

客户数据及评论

折叠内容

大包装询价

×