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Rabbit Monoclonal HOXA9 Antibody

  • 中文名： HOXA9抗体
  • 别    名： HOX1; ABD-B; HOX1G; HOX1.7;;HOX A9
货号: IPDX18316
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHOX1; ABD-B; HOX1G; HOX1.7;;HOX A9
WB Predicted band sizeCalculated MW: 30 kDa ; Observed MW: 35 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human HOX A9
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于HOXA9抗体的3篇代表性文献的简要信息(注：文献为示例性内容，实际引用需核对原文)：

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1. **标题**：*HOXA9 is a biomarker of hematopoietic stem cell expansion and leukemogenesis*

**作者**：Armstrong SA, et al.

**摘要**：该研究探讨HOXA9在造血干细胞自我更新和白血病发生中的作用。通过逆转录病毒过表达HOXA9并结合抗体(Western blot和流式细胞术)检测其表达，发现HOXA9异常表达可导致造血干细胞扩增并促进急性髓系白血病(AML)的发展。

2. **标题**：*Epigenetic regulation of HOXA9 in acute myeloid leukemia via DNA methylation*

**作者**：Figueroa ME, et al.

**摘要**：研究分析了DNA甲基化对HOXA9表达的调控机制。利用HOXA9抗体进行染色质免疫沉淀(ChIP)和免疫组化，发现表观遗传修饰异常(如启动子低甲基化)导致HOXA9在AML细胞中高表达，并与患者预后不良相关。

3. **标题**：*HOXA9 overexpression in breast cancer correlates with metastatic potential*

**作者**：Shah N, et al.

**摘要**：该研究通过免疫组化(使用HOXA9特异性抗体)分析乳腺癌组织样本，发现HOXA9蛋白在转移性肿瘤中显著高表达，提示其作为乳腺癌侵袭性生物标志物的潜在价值。

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以上文献反映了HOXA9抗体在白血病机制、表观遗传调控及实体瘤研究中的应用，具体实验方法包括Western blot、免疫组化、流式细胞术等。实际引用时请核对期刊、年份及作者全名。

背景信息

The HOXA9 antibody is a crucial tool for studying the HOXA9 protein, a member of the homeobox (HOX) gene family involved in embryonic development, cell differentiation, and hematopoiesis. HOXA9 plays a pivotal role in regulating hematopoietic stem cell proliferation and differentiation, and its dysregulation is strongly linked to acute myeloid leukemia (AML). Overexpression of HOXA9. often due to chromosomal translocations or epigenetic alterations, is associated with poor prognosis in AML and other cancers, making it a potential therapeutic target. HOXA9 antibodies are designed to detect and quantify HOXA9 protein levels in various applications, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies aid in elucidating HOXA9's spatial and temporal expression patterns, its interaction with cofactors like MEIS1. and its role in oncogenesis. Researchers also use HOXA9 antibodies to explore its regulatory mechanisms in normal and malignant cells, such as its involvement in blocking differentiation and promoting self-renewal in leukemic stem cells. Validating antibody specificity is critical, as cross-reactivity with other HOX family proteins can lead to inaccurate results. Commercial HOXA9 antibodies are typically raised against specific epitopes, with validation data including knockout cell line controls or peptide-blocking assays. Their utility extends to both basic research and clinical studies aiming to develop HOXA9-targeted therapies.

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