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Rabbit Monoclonal TRIM29 Antibody

  • 中文名： TRIM29抗体
  • 别    名： ATDC; TRIM29;;TRIM29
货号: IPDX18310
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesATDC; TRIM29;;TRIM29
WB Predicted band sizeCalculated MW: 66 kDa ; Observed MW: 68 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human TRIM29
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于TRIM29抗体的3篇参考文献，按文献名称、作者和摘要内容概括列出：

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1. **文献名称**：*TRIM29 promotes cell proliferation and invasion by enhancing Wnt/β-catenin signaling in gastric cancer*

**作者**：Li Y, et al.

**摘要**：研究通过免疫组化(使用TRIM29抗体)发现TRIM29在胃癌组织中高表达，且与患者预后不良相关。实验表明TRIM29通过激活Wnt/β-catenin信号通路促进肿瘤细胞增殖和侵袭。

2. **文献名称**：*TRIM29 as a novel biomarker in pancreatic ductal adenocarcinoma: Expression and clinical correlation*

**作者**：Wang X, et al.

**摘要**：利用TRIM29抗体进行组织微阵列分析，发现TRIM29在胰腺导管腺癌中显著高表达，并与肿瘤分期和转移相关。研究提示TRIM29可能成为胰腺癌诊断或治疗靶点。

3. **文献名称**：*The role of TRIM29 in DNA damage response and its interaction with p53 in breast cancer*

**作者**：Chen L, et al.

**摘要**：通过Western blot和免疫荧光(使用TRIM29特异性抗体)揭示TRIM29通过调控p53稳定性参与乳腺癌细胞的DNA损伤修复，抑制TRIM29可增强化疗敏感性。

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以上研究均基于TRIM29抗体的实验技术，探讨了其在肿瘤发生、诊断或治疗中的潜在作用。

背景信息

The TRIM29 antibody targets TRIM29 (Tripartite Motif-Containing 29), a protein encoded by the TRIM29 gene, which belongs to the TRIM family involved in diverse cellular processes like apoptosis, DNA repair, and antiviral responses. TRIM29. also known as ATDC (Ataxia-Telangiectasia Group D Complementing), is implicated in cancer biology, though its role is context-dependent, acting as both an oncogene and tumor suppressor. Structurally, it contains multiple zinc-binding domains (B-boxes) and a coiled-coil region but lacks a RING domain, distinguishing it from other TRIM proteins. TRIM29 interacts with p53. β-catenin, and other signaling molecules, modulating pathways like Wnt/β-catenin and NF-κB. Its overexpression is linked to tumor progression in pancreatic, bladder, and breast cancers, while downregulation is observed in certain carcinomas, suggesting tissue-specific functions. Antibodies against TRIM29 are used in research to study its expression patterns, subcellular localization (primarily nuclear or cytoplasmic), and interactions in cancer models. They aid in detecting TRIM29's involvement in chemotherapy resistance, metastasis, and immune evasion. However, inconsistent findings across studies highlight the need for standardized antibody validation. TRIM29 antibodies are critical tools for exploring its dual roles in carcinogenesis and potential as a diagnostic or therapeutic target.

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