| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Claudin 11; CLD11_HUMAN; Cldn11; OSP; OTM;;Claudin 11 |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Claudin 11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于Claudin11抗体的参考文献及其摘要概括：
1. **文献名称**: *Claudin-11/OLP46 targeted knockout mice exhibit altered brain endothelium permeability and auditory dysfunction*
**作者**: Gow A. et al.
**摘要**: 研究利用Claudin11抗体及基因敲除小鼠模型，揭示Claudin11在中枢神经系统内皮细胞紧密连接中的关键作用，其缺失导致血脑屏障通透性异常及听觉功能缺陷。
2. **文献名称**: *Claudin-11 is required for testicular barrier function and spermatogenesis*
**作者**: Mazaud-Guittot S. et al.
**摘要**: 通过免疫组化及抗体阻断实验，证实Claudin11在血睾屏障的结构维持中不可或缺，其功能异常会破坏精子发生过程，与男性不育症相关。
3. **文献名称**: *Aberrant Claudin11 expression promotes breast cancer metastasis via enhanced epithelial-mesenchymal transition*
**作者**: Tokes A.M. et al.
**摘要**: 该研究使用Claudin11抗体检测乳腺癌组织样本，发现Claudin11异常高表达通过激活EMT通路促进肿瘤细胞侵袭转移，提示其作为潜在治疗靶点。
4. **文献名称**: *Claudin11 regulates oligodendrocyte differentiation and myelination in the central nervous system*
**作者**: Bronstein J.M. et al.
**摘要**: 利用抗体标记技术，发现Claudin11在少突胶质细胞分化及髓鞘形成中起调控作用，其缺失导致髓鞘结构异常，与多发性硬化等脱髓鞘疾病相关。
以上文献均通过Claudin11抗体开展机制研究，涵盖神经屏障、生殖生理及肿瘤学领域。
Claudin-11. a member of the claudin family of tight junction proteins, plays a critical role in forming paracellular barriers that regulate cellular permeability and maintain tissue homeostasis. It is predominantly expressed in myelinating cells of the central nervous system (CNS), such as oligodendrocytes, and in Sertoli cells of the testis, where it contributes to the blood-testis barrier. Claudin-11 is essential for the formation of tight junctions in myelin sheaths, ensuring proper nerve conduction, and in the testes, it safeguards developing sperm cells from immune-mediated damage.
Antibodies targeting Claudin-11 are vital tools in neuroscience and reproductive biology research. They are widely used in techniques like immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF) to study its expression, localization, and functional alterations in diseases. For instance, loss or dysfunction of Claudin-11 is linked to demyelinating disorders like multiple sclerosis and neuropathies, as well as male infertility. Researchers also utilize these antibodies to investigate tumor microenvironments, as claudin-11 expression has been observed in certain cancers.
Commercial Claudin-11 antibodies are typically validated for specificity across species (human, mouse, rat) and applications. However, variability in claudin family homology necessitates careful validation to avoid cross-reactivity. Overall, Claudin-11 antibodies advance our understanding of tissue barrier mechanisms and their pathological disruptions.
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