| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Meis homeobox 2; Meis1 related gene 1; MEIS2; MGC2820; MRG1;;MEIS2 |
| WB Predicted band size | 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human MEIS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于MEIS2抗体的3篇参考文献示例(模拟虚构内容，仅供参考格式)：
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1. **标题**: *MEIS2 Antibody Validation and Its Role in Neural Crest Development*
**作者**: Smith A, et al. (2018)
**摘要**: 本研究通过Western blot和免疫组化验证了MEIS2抗体的特异性，发现其在胚胎小鼠神经嵴细胞中高表达。抗体成功用于追踪MEIS2在神经管闭合过程中的动态表达，提示其在神经系统发育中的关键作用。
2. **标题**: *MEIS2 as a Biomarker in Pediatric Brain Tumors: An Immunohistochemical Study*
**作者**: Zhang L, et al. (2020)
**摘要**: 利用MEIS2抗体对200例儿童脑瘤样本进行染色，发现其在髓母细胞瘤中表达显著升高，且与MYC扩增相关。研究表明MEIS2抗体可作为鉴别肿瘤亚型的潜在工具。
3. **标题**: *Comparative Analysis of MEIS2 Antibody Clones in Cardiac Tissue Staining*
**作者**: Braun C, et al. (2016)
**摘要**: 对比了三种商业MEIS2抗体在小鼠心脏组织的染色效果，发现Clone 3H9在心肌细胞核内信号最强且背景低。研究为心脏发育中MEIS2功能研究提供了抗体选择依据。
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(注：以上文献为示例，实际引用需查询真实数据库如PubMed。)
The MEIS2 antibody is a crucial tool in studying the MEIS2 protein, a member of the TALE (three-amino-acid-loop-extension) homeodomain family of transcription factors. MEIS2 plays pivotal roles in embryonic development, particularly in organogenesis, neurogenesis, and limb patterning. It interacts with HOX proteins and other cofactors to regulate gene expression, influencing cellular differentiation and tissue morphogenesis. Dysregulation of MEIS2 has been linked to developmental disorders, including intellectual disabilities, autism spectrum disorders, and congenital anomalies like cleft palate. It is also implicated in cancers, such as neuroblastoma and leukemia, where its aberrant expression may drive tumor progression.
The MEIS2 antibody is widely used in research to detect and quantify MEIS2 protein levels via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It helps map MEIS2's spatial and temporal expression patterns in tissues, shedding light on its role in developmental pathways and disease mechanisms. Commercial MEIS2 antibodies are typically validated for specificity and sensitivity, though variability in isoforms (e.g., MEIS2A, MEIS2B) requires careful selection for experimental contexts. Recent studies also utilize MEIS2 antibodies in ChIP-seq to identify genome-wide binding sites, revealing its regulatory networks. Overall, this antibody is indispensable for unraveling MEIS2's biological functions and therapeutic potential.
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