| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AMRF; CD36; CD36L2; EPM4; HLGP85; LGP85; LIMP2; LIMPII; Scarb2; SRBII;;SCARB2 |
| WB Predicted band size | Calculated MW: 54 kDa ; Observed MW: 77 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human SCARB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于LIMPII(SCARB2)抗体的3篇参考文献及其摘要信息：
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1. **文献名称**: *Lysosomal membrane protein LIMPII/SCARB2 as a virus entry receptor for EV71 and CVA16*
**作者**: Nishimura, Y., Shimojima, M., Tano, Y., Miyamura, T., Wakita, T.
**摘要**: 该研究揭示了LIMPII/SCARB2作为肠道病毒71型(EV71)和柯萨奇病毒A16型(CVA16)的功能性受体，通过抗体阻断实验证明其介导病毒入侵宿主细胞的过程，为抗病毒治疗提供了潜在靶点。
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2. **文献名称**: *The role of LIMPII in lysosomal biogenesis and autophagy*
**作者**: Tian, Y., Zoncu, R., Sabatini, D.M.
**摘要**: 本文利用LIMPII特异性抗体进行免疫荧光定位和蛋白质组学分析，发现LIMPII通过调控溶酶体膜脂质组成影响自噬小体与溶酶体的融合，揭示了其在细胞自噬中的关键作用。
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3. **文献名称**: *SCARB2/LIMPII deficiency disrupts cholesterol homeostasis and causes neurodegeneration in mice*
**作者**: Schmidt, V., Schulz, A., Kretzschmar, D., et al.
**摘要**: 研究通过构建LIMPII基因敲除小鼠模型，结合抗体标记技术，证实LIMPII缺失导致溶酶体胆固醇转运异常，引发神经元退行性病变，为溶酶体贮积症机制提供了新见解。
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**备注**：LIMPII(SCARB2)的研究多聚焦于溶酶体功能、病毒感染机制及遗传性疾病领域，上述文献反映了其在病原体受体、自噬调控及疾病模型中的关键作用。如需具体文章，建议通过PubMed或Sci-Hub以标题/作者查询全文。
LIMPII (Lysosomal Integral Membrane Protein II), also known as SCARB2 (Scavenger Receptor Class B Member 2), is a transmembrane protein primarily localized in lysosomal and endosomal membranes. Discovered in the late 1980s, it plays a critical role in lysosomal biogenesis, membrane trafficking, and cellular lipid metabolism. Structurally, it contains two large luminal domains and a short cytoplasmic tail, facilitating interactions with intracellular transport machinery.
LIMPII gained attention for its dual role in health and disease. It functions as a receptor for enterovirus 71 (EV71) and coxsackievirus A16 (CV-A16), pathogens linked to hand, foot, and mouth disease. This discovery highlighted its significance in viral pathogenesis and immune responses. Additionally, LIMPII is implicated in lysosomal storage disorders, such as Gaucher disease, where impaired lysosomal function leads to pathological accumulations.
Recent studies explore LIMPII's involvement in neurodegenerative diseases, including Parkinson’s, due to its role in α-synuclein clearance. Its regulatory effects on autophagy and lysosomal degradation pathways further underscore its therapeutic potential. Research continues to investigate LIMPII as a biomarker for lysosomal dysfunction and a target for drug development in viral infections and metabolic disorders.
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