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Rabbit Monoclonal Gemin2 Antibody

  • 中文名： Gemin2抗体
  • 别    名： gemin2; SIP 1; SIP1; SIP1 delta; SMN interacting protein 1; Survival interacting protein 1;;Gemin 2
货号: IPDX18007
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliasesgemin2; SIP 1; SIP1; SIP1 delta; SMN interacting protein 1;  Survival interacting protein 1;;Gemin 2
WB Predicted band sizeCalculated MW: 32 kDa ; Observed MW: 31 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Gemin 2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇关于Gemin2抗体的参考文献概览(基于公开文献内容整合，非真实存在的文献，仅供示例参考)：

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1. **文献名称**: *Gemin2 modulates SMN complex formation in spinal muscular atrophy*

**作者**: Gubitz AK, et al.

**摘要**: 研究利用Gemin2特异性抗体进行免疫共沉淀实验，揭示了Gemin2在SMN(survival of motor neuron)复合体组装中的关键作用，并发现其缺失导致脊髓性肌萎缩症(SMA)模型中的运动神经元功能障碍。

2. **文献名称**: *Antibody-based profiling of Gemin2 interactions in Cajal bodies*

**作者**: Matera AG, et al.

**摘要**: 通过免疫荧光结合Gemin2抗体，研究证实Gemin2在Cajal体中的定位依赖于SMN蛋白，并揭示了其在snRNP(小核糖核蛋白颗粒)生物发生中的动态调控机制。

3. **文献名称**: *Characterization of a novel monoclonal antibody against Gemin2 for diagnostic applications*

**作者**: Liu Y, et al.

**摘要**: 报道了一种新型Gemin2单克隆抗体的开发与验证，该抗体在Western blot和免疫组化中表现出高特异性，可用于SMA患者的分子诊断和病理机制研究。

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注：以上文献为示例性内容，实际引用时需核对真实存在的文献数据库(如PubMed)。如需真实文献，建议通过关键词“Gemin2 antibody”或“Gemin2 SMN complex”检索相关学术平台。

背景信息

The Gemin2 antibody is a crucial tool for studying the survival motor neuron (SMN) complex, a multi-protein assembly essential for the biogenesis of small nuclear ribonucleoproteins (snRNPs) involved in pre-mRNA splicing. Gemin2 (also known as SIP1) is a core component of the SMN complex, directly interacting with SMN1. the protein deficient in spinal muscular atrophy (SMA). It facilitates the assembly of Sm proteins onto snRNA, a critical step in snRNP maturation. Antibodies targeting Gemin2 are widely used in research to investigate SMN complex formation, localization, and function, particularly in the context of SMA pathogenesis and snRNP biogenesis defects. These antibodies enable techniques like Western blotting, immunoprecipitation, and immunofluorescence to assess Gemin2 expression levels, protein-protein interactions, and subcellular distribution. Commercially available Gemin2 antibodies are typically raised in rabbits or mice against specific epitopes of human Gemin2. with validation in common model organisms. Their application has advanced understanding of spliceosome assembly mechanisms and SMN complex dynamics in both healthy and diseased states, offering insights into therapeutic strategies for neuromuscular disorders.

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