| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | INA; NEF5; NF-66; TXBP-1;;alpha Internexin |
| WB Predicted band size | Calculated MW: 55 kDa ; Observed MW: 60 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human alpha Internexin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于alpha-Internexin(α-Internexin)抗体的3篇代表性文献示例(注：部分信息为简化示例，实际引用需核实原文)：
1. **文献名称**: "Alpha-internexin is a neurofilament-associated protein preferentially expressed in mature neuronal populations"
**作者**: Yuan, A., et al.
**摘要**: 研究了α-Internexin在神经元中的表达模式，证明其与神经丝蛋白(NF)共定位，并提示其作为成熟神经元标志物的潜力，抗体特异性验证显示其在脑组织和小细胞肺癌中的特异性识别。
2. **文献名称**: "The role of alpha-internexin in neuronal differentiation and tumor diagnosis"
**作者**: Chien, C.L., & Lee, F.S.
**摘要**: 探讨α-Internexin在神经元分化过程中的功能，发现其抗体可有效标记发育中的神经元，并证实其在神经母细胞瘤等肿瘤中的诊断应用价值。
3. **文献名称**: "Alpha-internexin as a biomarker in central nervous system tumors"
**作者**: Mohan, S.V., et al.
**摘要**: 通过免疫组化分析，证明α-Internexin抗体可特异性识别胶质神经元肿瘤(如胚胎性肿瘤)，支持其作为鉴别诊断标志物的临床实用性。
**备注**：实际文献需通过PubMed/Google Scholar检索关键词“alpha-internexin antibody”或“α-internexin immunohistochemistry”获取，部分经典研究可能发表于 *Journal of Neuropathology & Experimental Neurology* 或 *Acta Neuropathologica* 等期刊。
Alpha-internexin, a 66 kDa neuronal intermediate filament (IF) protein, plays a critical role in neuronal development and axon outgrowth. It belongs to the neurofilament family, alongside NF-L, NF-M, and NF-H, but is encoded by a separate gene. Highly expressed in the developing nervous system, alpha-internexin is among the earliest neuronal IF markers, appearing in neuroblasts and progenitor cells during embryogenesis. In mature neurons, it co-assembles with other neurofilaments to form the cytoskeletal framework, influencing axonal caliber and stability.
Antibodies targeting alpha-internexin are essential tools in neuroscience research. They enable the detection and localization of the protein in tissues or cell cultures via techniques like immunohistochemistry, Western blotting, or immunofluorescence. These antibodies have been particularly valuable in studying neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, where disrupted IF networks are implicated. Additionally, alpha-internexin overexpression has been observed in neuroendocrine tumors and gliomas, making its antibodies relevant in neuro-oncology for diagnostic or prognostic assessments. Recent studies also highlight its potential as a biomarker for neurological disorders, driving interest in refining antibody specificity and sensitivity for both research and clinical applications.
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