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Rabbit Monoclonal ESE1 Antibody

  • 中文名： ESE1抗体
  • 别    名： Elf3; EPR1; ERT; ESE-1; ESX; jen;;ELF3
货号: IPDX18006
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesElf3; EPR1; ERT; ESE-1; ESX; jen;;ELF3
WB Predicted band sizeCalculated MW: 41 kDa ; Observed MW: 47 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human ELF3
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于ESE1抗体的3篇参考文献及其摘要内容的简要列举：

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1. **文献名称**：*ESE1/ELF3 regulates the expression of ITGA2 in colorectal cancer*

**作者**：Li Y, et al.

**摘要**：该研究使用抗ESE1抗体通过免疫组化和Western blot分析结直肠癌组织中ESE1蛋白的表达，发现其通过调控ITGA2基因促进肿瘤侵袭，证实抗体在检测肿瘤特异性表达中的应用。

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2. **文献名称**：*Role of ESE1 in epithelial inflammation and NF-κB activation*

**作者**：Wang H, et al.

**摘要**：研究利用ESE1抗体进行ChIP-seq和免疫荧光实验，揭示ESE1在炎症反应中与NF-κB通路相互作用，抗体用于定位其核内活性及靶基因结合机制。

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3. **文献名称**：*Antibody validation for ESE1 in prostate cancer progression*

**作者**：Smith J, et al.

**摘要**：通过抗体验证(敲除/过表达模型)评估ESE1抗体的特异性，证明其在前列腺癌中高表达并与患者预后相关，强调抗体在临床样本检测中的可靠性。

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注：以上文献信息为示例，实际引用需根据具体论文核实。建议通过PubMed或Google Scholar以关键词“ESE1 antibody”或“ELF3 antibody”检索最新研究。

背景信息

The ESE1 antibody targets the ESE1 protein, also known as Elf3 or ERT, a member of the ETS family of transcription factors. ESE1 is primarily expressed in epithelial tissues and plays a critical role in regulating genes involved in cell differentiation, inflammation, and stress responses. It binds to DNA via its conserved ETS domain, modulating pathways like NF-κB and MAPK, which are pivotal in maintaining epithelial homeostasis and responding to pathological conditions. Dysregulation of ESE1 has been implicated in cancers (e.g., breast, prostate, and colon), chronic inflammatory diseases, and tissue injury. Researchers use ESE1 antibodies in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study its expression patterns, subcellular localization, and interactions in both normal and diseased states. These studies aim to elucidate ESE1's dual role as a tumor suppressor or promoter, depending on cellular context, and its potential as a therapeutic target. The antibody's specificity and reliability make it a valuable tool for exploring epithelial biology and disease mechanisms.

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