| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HNC; CLG1; MMP-8; PMNL-CL; COLLAGENASE I; NEUTROPHIL; matrix metalloproteinase 8;;MMP8 |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human MMP8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于MMP8抗体的模拟参考文献(内容为示例性概括，非真实文献)：
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1. **文献名称**：*MMP-8 Monoclonal Antibody for Early Diagnosis of Periodontitis*
**作者**：Smith A, et al.
**摘要**：研究开发了一种高特异性MMP8单克隆抗体，通过唾液样本检测MMP8活性水平，发现其在牙周炎早期诊断中具有高灵敏度和特异性，为无创筛查提供新工具。
2. **文献名称**：*Role of MMP8 in Tumor Metastasis: Antibody-Based Inhibition Study*
**作者**：Chen L, et al.
**摘要**：利用抗MMP8抗体阻断其酶活性，发现可显著抑制乳腺癌细胞侵袭和转移，提示MMP8抗体在癌症靶向治疗中的潜在应用价值。
3. **文献名称**：*MMP8 as a Biomarker in Chronic Wound Healing: Immunoassay Development*
**作者**：Johnson R, et al.
**摘要**：通过ELISA和免疫组化技术验证MMP8抗体在慢性伤口组织中的高表达，表明MMP8水平与愈合延迟相关，可作为预后标志物指导临床干预。
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**备注**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词“MMP8 antibody”或结合具体研究领域筛选。
**Background of MMP8 Antibody**
Matrix metalloproteinase 8 (MMP8), also known as neutrophil collagenase, is a member of the MMP family involved in extracellular matrix (ECM) remodeling. It primarily cleaves type I, II, and III collagens, playing roles in inflammation, tissue repair, and immune responses. MMP8 is secreted by neutrophils, fibroblasts, and endothelial cells as an inactive zymogen, requiring proteolytic activation. Dysregulation of MMP8 is linked to pathologies such as cancer, arthritis, cardiovascular diseases, and chronic wounds.
MMP8 antibodies are essential tools for detecting and quantifying MMP8 expression in research and diagnostics. They enable studies on MMP8's dual role in disease—acting as both a promoter and suppressor depending on context. For example, in cancer, MMP8 may inhibit tumor progression by modulating immune responses or promote metastasis by degrading ECM barriers. Antibodies targeting specific MMP8 epitopes (e.g., catalytic or hemopexin domains) are used in techniques like ELISA, Western blot, immunohistochemistry, and flow cytometry.
Recent studies highlight MMP8's potential as a biomarker. Elevated MMP8 levels correlate with poor prognosis in cancers and inflammatory conditions. Neutralizing antibodies are also explored for therapeutic strategies to inhibit excessive MMP8 activity. However, cross-reactivity with other MMPs remains a challenge, emphasizing the need for highly specific antibodies. Overall, MMP8 antibodies advance understanding of ECM dynamics and therapeutic targeting in complex diseases.
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