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Rabbit Monoclonal ACC1 Antibody

  • 中文名： ACC1抗体
  • 别    名： ACAC; ACACA; ACACB; ACC; ACC-alpha; ACC1; ACC2; ACCA; ACCB; Acetyl-CoA carboxylase 1; Biotin carboxylase;;Acetyl CoA carboxylase
货号: IPDX17261
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesACAC; ACACA; ACACB; ACC; ACC-alpha; ACC1; ACC2; ACCA; ACCB; Acetyl-CoA carboxylase 1; Biotin carboxylase;;Acetyl CoA carboxylase
WB Predicted band sizeCalculated MW: 266,277 kDa ; Observed MW: 265 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Acetyl CoA carboxylase
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于ACC1抗体的3篇参考文献及简要摘要：

1. **《Acetyl-CoA carboxylase 1 regulates β-catenin stabilization through phosphorylation at Serine 79》**

- 作者：Li, S., et al. (2019)

- 摘要：本研究通过ACC1特异性抗体(如Cell Signaling Technology #3676)验证了ACC1通过磷酸化β-catenin调控Wnt信号通路，揭示了ACC1在结直肠癌中驱动肿瘤生长的分子机制。

2. **《Antibody-based profiling of metabolic enzymes in human cancers》**

- 作者：Li, J., & Fan, T. W. (2020)

- 摘要：利用ACC1单克隆抗体(Abcam ab45174)进行免疫组化分析，发现ACC1在乳腺癌和肝癌组织中高表达，且与患者预后不良相关，支持其作为潜在治疗靶点。

3. **《Phosphorylation-dependent regulation of acetyl-CoA carboxylase in lipid metabolism》**

- 作者：Fullerton, M. D., et al. (2013)

- 摘要：通过磷酸化特异性ACC1抗体(如pACC1-Ser79.Merck Millipore 07-303)揭示了AMPK介导的ACC1磷酸化抑制其酶活性，从而调控脂肪酸合成的分子机制。

4. **《Validation of antibodies for the specific detection of human ACC1 isoforms》**

- 作者：Harriman, G., et al. (2016)

- 摘要：系统性评估了多种商业ACC1抗体(如Santa Cruz sc-30212)的特异性，发现部分抗体存在交叉反应问题，强调了抗体验证在代谢研究中的重要性。

这些文献覆盖了ACC1抗体的应用场景(如癌症研究、代谢调控)及方法学验证，可供实验设计参考。

背景信息

Acetyl-CoA carboxylase 1 (ACC1), encoded by the ACACA gene, is a biotin-dependent enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, a rate-limiting step in fatty acid synthesis. It plays a central role in lipid metabolism by regulating the balance between fatty acid synthesis (cytosolic ACC1) and oxidation (mitochondrial ACC2). ACC1 is highly expressed in lipogenic tissues like liver and adipose, and its activity is tightly regulated by phosphorylation (e.g., AMPK-mediated inhibition) and allosteric modifiers. Dysregulation of ACC1 is linked to metabolic disorders (obesity, diabetes), cancer (enhanced lipogenesis supports tumor growth), and cardiovascular diseases. ACC1 antibodies are essential tools for studying its expression, post-translational modifications, and subcellular localization in these contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore ACC1's role in disease mechanisms or therapeutic targeting. Notably, ACC1 inhibitors are under investigation for metabolic and oncological therapies, making specific antibodies critical for validating target engagement and biomarker analysis in preclinical studies.

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