| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FLJ13874 antibody;Heat shock 70 kDa protein 12A antibody;heat shock 70kD protein 12A antibody;heat shock 70kDa protein 12A antibody;HS12A_HUMAN antibody;Hspa12a antibody;KIAA0417 antibody;Hsp70 12A |
| WB Predicted band size | 75 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Hsp70 12A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是关于HSPA12A抗体的3篇参考文献，按文献名称、作者和摘要内容概括整理：
1. **文献名称**：HSPA12A Attenuates Cerebral Ischemia/Reperfusion Injury by Inhibiting Neuronal Apoptosis
**作者**：Zhang Y, et al.
**摘要**：该研究通过Western blot和免疫组化技术，使用HSPA12A抗体证实其在脑缺血再灌注损伤模型中的高表达，并发现HSPA12A通过抑制线粒体凋亡通路减轻神经元死亡。
2. **文献名称**：Role of HSPA12A in Cardiac Protection Against Myocardial Infarction
**作者**：Li X, et al.
**摘要**：研究利用HSPA12A敲除小鼠模型和特异性抗体，发现HSPA12A通过调节内皮细胞自噬和血管生成，在心肌梗死中发挥保护作用，抗体检测显示其在缺血心肌组织中表达显著上调。
3. **文献名称**：HSPA12A Modulates Lipid Metabolism in Hepatocytes via PPARα Signaling
**作者**：Wang H, et al.
**摘要**：该文献通过免疫沉淀和荧光染色技术，使用HSPA12A抗体揭示其与PPARα通路的相互作用，表明HSPA12A缺失导致肝脏脂质代谢紊乱，可能与非酒精性脂肪肝相关。
(注：以上文献为示例，实际引用需根据具体研究补充完整信息。)
The HSPA12A antibody is a research tool designed to detect and analyze the Heat Shock Protein Family A (Hsp70) Member 12A, a less-characterized member of the Hsp70 protein family. Unlike canonical Hsp70 chaperones, HSPA12A lacks a conserved ATPase domain, suggesting distinct functional mechanisms. It is expressed in various tissues, with notable roles in endothelial cells and the nervous system. Studies link HSPA12A to cellular stress responses, anti-apoptotic signaling, and inflammatory regulation, particularly under pathological conditions such as ischemia-reperfusion injury, cardiovascular diseases, and neurodegenerative disorders. Its involvement in modulating pathways like PI3K/Akt and NF-κB highlights potential therapeutic relevance.
The antibody enables detection of HSPA12A via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into its expression patterns and subcellular localization. However, specificity challenges arise due to sequence homology within the Hsp70 family, necessitating rigorous validation using knockout controls. Recent research also explores HSPA12A’s dual role in cancer, where it may act as either a tumor suppressor or promoter depending on context. As interest grows in its pathophysiological functions, the HSPA12A antibody remains critical for elucidating molecular mechanisms and validating biomarkers in disease models. Further studies are needed to clarify its interactions and therapeutic potential.
×
