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Rabbit Monoclonal TACC3 Antibody

  • 中文名: TACC3抗体
  • 别    名: ERIC-1; ERIC1; TAC3; Transforming acidic coiled-coil-containing protein 3;TACC3;;TACC3
货号: IPDX17060
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesERIC-1; ERIC1; TAC3; Transforming acidic coiled-coil-containing protein 3;TACC3;;TACC3
WB Predicted band sizeCalculated MW: 90 kDa ; Observed MW: 140 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human TACC3
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于TACC3抗体的3-4篇示例参考文献(注:以下为假设性示例,实际引用请核实真实文献):

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1. **"TACC3 expression in breast cancer: Clinical significance and antibody-based detection"**

*Lauffart, B. et al. (2015).*

摘要:研究利用特异性TACC3抗体,通过免疫组化分析乳腺癌组织中TACC3蛋白的表达水平,发现其过表达与肿瘤分级和不良预后显著相关,提示其作为潜在生物标志物的价值。

2. **"Functional characterization of anti-TACC3 antibodies in cancer cell proliferation"**

*Huang, Y. et al. (2018).*

摘要:开发了一种高特异性TACC3单克隆抗体,体外实验显示其可抑制肿瘤细胞的有丝分裂和增殖,机制与干扰纺锤体稳定性及阻滞细胞周期相关。

3. **"Structural insights into TACC3-antibody interactions by cryo-EM"**

*Gómez-Balderas, R. et al. (2020).*

摘要:通过冷冻电镜解析TACC3蛋白与其单克隆抗体的复合物结构,揭示了抗体结合域的关键位点,为靶向TACC3的抗体药物设计提供结构基础。

4. **"TACC3 antibody application in myeloma research"**

*Barton, E. et al. (2019).*

摘要:研究在多发性骨髓瘤模型中利用TACC3抗体进行功能阻断实验,证明TACC3通过调控Aurora激酶信号通路促进肿瘤存活,抗体干预可显著增强化疗敏感性。

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**提示**:实际研究中,建议通过PubMed或Google Scholar以关键词“TACC3 antibody”或“anti-TACC3”检索最新文献,并优先选择高影响力期刊或权威团队的研究成果。

背景信息

The TACC3 (Transforming Acidic Coiled-Coil Containing Protein 3) antibody is a research tool designed to target the TACC3 protein, a member of the TACC family involved in critical cellular processes such as mitotic spindle assembly, centrosome dynamics, and microtubule stabilization. TACC3 is predominantly expressed during mitosis and plays a role in cell cycle regulation, particularly in chromosome segregation and cytokinesis. Dysregulation of TACC3 has been linked to various cancers, including breast, ovarian, and lung cancers, where its overexpression correlates with tumor aggressiveness and poor prognosis. The antibody, typically developed as polyclonal or monoclonal, is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study TACC3's expression patterns, subcellular localization, and interaction partners. Recent studies highlight its involvement in cancer stem cell maintenance, DNA damage response, and epigenetic regulation, making it a potential therapeutic target. Additionally, TACC3 antibodies aid in exploring its role in developmental processes and neurological disorders. Validating antibody specificity remains crucial, as cross-reactivity with other TACC family members (TACC1/2) can occur. Overall, TACC3 antibodies are essential for deciphering the protein's biological functions and its implications in disease mechanisms.

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