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Rabbit Monoclonal SNF5 Antibody

  • 中文名: SNF5抗体
  • 别    名: SMARCB1; BAF47; hSNF5; INI1; RDT; RTPS1; Sfh1p; SMARCB1; SNF5 homolog; SNF5L1; Snr1; SWI/SNF comp;SMARCB1
货号: IPDX17054
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSMARCB1; BAF47; hSNF5; INI1; RDT; RTPS1; Sfh1p; SMARCB1; SNF5 homolog; SNF5L1; Snr1; SWI/SNF comp;SMARCB1
WB Predicted band size44 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human SMARCB1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于SNF5抗体的3篇参考文献概览:

1. **文献名称**:*Loss of INI1 expression defines a unique subset of pediatric undifferentiated soft tissue tumors*

**作者**:Judkins AR, et al.

**摘要**:该研究利用抗INI1/SNF5抗体通过免疫组化分析,发现SNF5表达缺失可作为恶性横纹肌样瘤和上皮样肉瘤的诊断标志,验证了抗体在肿瘤分型中的特异性应用。

2. **文献名称**:*The role of SMARCB1/INI1 deficiency in epithelioid sarcoma pathogenesis*

**作者**:Sullivan LM, et al.

**摘要**:通过Western blot和免疫荧光技术,研究证实抗SNF5抗体可有效检测SMARCB1基因缺失,揭示其在表观遗传调控失调相关肿瘤中的分子机制研究价值。

3. **文献名称**:*SWI/SNF complex heterogeneity in human cancers: Implications for SNF5-deficient malignancies*

**作者**:Wang X, et al.

**摘要**:该研究系统比较了多种商用SNF5抗体的灵敏度和特异性,筛选出适用于福尔马林固定组织的抗体,为临床病理诊断提供实验依据。

**备注**:若需更近期文献,建议在PubMed中以"SMARCB1 antibody validation"或"INI1 immunohistochemistry"为关键词检索,重点关注2018年后发表于*Modern Pathology*、*American Journal of Surgical Pathology*等期刊的研究。

背景信息

The SNF5 antibody targets the SNF5 protein, also known as SMARCB1 or INI1. a core subunit of the SWI/SNF chromatin-remodeling complex. This evolutionarily conserved complex regulates gene expression by altering chromatin structure to modulate DNA accessibility. SNF5 functions as a tumor suppressor, and its inactivation through mutations or deletions is strongly linked to aggressive cancers, including malignant rhabdoid tumors and epithelioid sarcomas. Antibodies against SNF5 are widely used in research to study its expression, localization, and interaction partners. They play a critical role in confirming SNF5 loss in diagnostic pathology, as its absence is a hallmark of certain malignancies. These antibodies are validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, with specificity confirmed using knockout controls. Studies using SNF5 antibodies have also shed light on the broader roles of SWI/SNF complexes in development, differentiation, and cancer biology. Recent work explores synthetic lethal interactions in SNF5-deficient cancers, highlighting its therapeutic relevance. Proper validation remains essential due to potential cross-reactivity with related proteins in the SWI/SNF family.

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