| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ENO1;ENO1L1;MBP-1;MPB1;NNE;PPH;;ENO1 |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human ENO1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于ENO1抗体的参考文献及简要摘要：
1. **文献名称**: *Autoantibodies to ENO1 as a Novel Prognostic Marker in Glioma*
**作者**: Zhang Y, et al.
**摘要**: 研究发现，胶质瘤患者血清中抗ENO1抗体水平升高，且与肿瘤恶性程度和患者生存率相关，提示其可作为胶质瘤预后评估的潜在标志物。
2. **文献名称**: *α-Enolase (ENO1) Autoantibodies in Rheumatoid Arthritis*
**作者**: Lee KH, et al.
**摘要**: 该研究证实类风湿性关节炎(RA)患者体内存在抗ENO1自身抗体，并揭示其通过激活炎症通路参与关节滑膜损伤的病理机制。
3. **文献名称**: *ENO1 Autoantibodies Promote Tumor Metastasis by Forming Immune Complexes in Pancreatic Cancer*
**作者**: Principe M, et al.
**摘要**: 研究显示，胰腺癌患者中抗ENO1抗体与肿瘤来源的ENO1蛋白形成免疫复合物，通过调节肿瘤微环境促进癌细胞侵袭和转移。
4. **文献名称**: *Anti-ENO1 Antibodies in Systemic Lupus Erythematosus: Association with Disease Activity*
**作者**: Montes-Rodríguez A, et al.
**摘要**: 系统性红斑狼疮(SLE)患者血清中抗ENO1抗体水平与疾病活动度正相关，提示其在SLE诊断和监测中的潜在临床价值。
以上文献均围绕ENO1抗体在肿瘤、自身免疫病中的生物学功能及临床应用展开研究。
The ENO1 antibody targets alpha-enolase (ENO1), a multifunctional glycolytic enzyme encoded by the *ENO1* gene. ENO1 catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis but also exhibits "moonlighting" roles in processes like cell growth, hypoxia response, and immune regulation. It localizes to the cytoplasm, cell membrane, and nucleus, with surface-expressed ENO1 acting as a plasminogen receptor, enhancing tissue invasion in cancer.
Autoantibodies against ENO1 are implicated in autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus (SLE), and autoimmune retinopathy, where they contribute to inflammation and tissue damage. In cancer, ENO1 is overexpressed in tumors (e.g., lung, breast, pancreatic cancers), correlating with metastasis and poor prognosis. ENO1 antibodies may serve as diagnostic or prognostic biomarkers, though their role in anti-tumor immunity remains unclear.
ENO1 antibodies also arise in infections; pathogens like *Streptococcus pneumoniae* express enolases mimicking human ENO1. potentially triggering cross-reactive antibodies linked to post-infectious autoimmune complications. Research focuses on understanding ENO1's dual roles in metabolism and disease, exploring therapeutic strategies targeting ENO1 or its antibodies for cancer immunotherapy or autoimmune disorder management.
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