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Mouse Monoclonal PRX Antibody

  • 中文名: PRX抗体
  • 别    名: nan
货号: IPDX15956
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human PRX
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于PRX(以Peroxiredoxin为例)抗体的虚构参考文献示例,供参考格式使用。实际文献需通过学术数据库查询:

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1. **文献名称**: *Peroxiredoxin Antibodies as Biomarkers in Neurodegenerative Disorders*

**作者**: Smith A, et al.

**摘要**: 研究探讨了PRX抗体检测脑脊液中Peroxiredoxin水平在阿尔茨海默病和帕金森病中的诊断价值,发现PRX表达升高与神经元氧化损伤程度相关,提示其作为早期生物标志物的潜力。

2. **文献名称**: *Monoclonal Antibody Targeting PRX1 Enhances Chemotherapy Sensitivity in Solid Tumors*

**作者**: Lee B, et al.

**摘要**: 开发了一种靶向PRX1的单克隆抗体,通过抑制癌细胞的抗氧化防御系统,显著增强化疗药物对肺癌和乳腺癌细胞的杀伤效果,为联合治疗提供新策略。

3. **文献名称**: *Structural Characterization of PRX3-Antibody Complexes for Therapeutic Applications*

**作者**: Garcia R, et al.

**摘要**: 利用冷冻电镜解析PRX3蛋白与中和抗体的结合表位,阐明其抑制氧化应激的关键机制,为设计针对心血管疾病的抗体药物提供结构基础。

4. **文献名称**: *PRX6 Autoantibodies in Autoimmune Disease Pathogenesis*

**作者**: Chen L, et al.

**摘要**: 发现系统性红斑狼疮患者血清中PRX6自身抗体水平异常升高,实验证实这些抗体通过干扰细胞氧化还原平衡加剧炎症反应,提示其参与自身免疫病理过程。

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**注意**:以上为示例性内容,非真实文献。建议通过PubMed、Web of Science等平台检索关键词“Peroxiredoxin antibody”或结合具体PRX亚型(如PRX1/PRX3/PRX6)获取最新研究。

背景信息

PRX antibodies target peroxiredoxin (PRX) proteins, a highly conserved family of antioxidant enzymes critical for regulating cellular redox homeostasis. First identified in the 1980s, PRX proteins are classified into six subtypes (PRX1-6) that catalyze the reduction of peroxides, protecting cells from oxidative damage caused by reactive oxygen species (ROS). Beyond their antioxidant role, PRXs participate in signaling pathways, immune response modulation, and apoptosis regulation. Dysregulation of PRX expression or activity is linked to cancer, neurodegenerative diseases, diabetes, and inflammatory disorders. For example, PRX1/2 are overexpressed in multiple cancers, correlating with tumor progression and therapy resistance, while PRX3/4 are associated with mitochondrial function and apoptosis. PRX antibodies are essential tools in biomedical research, enabling detection of PRX isoforms in tissues, cell lines, or biological fluids via techniques like Western blot, immunohistochemistry, and ELISA. They also aid in studying PRX interactions, post-translational modifications (e.g., hyperoxidation), and subcellular localization. Some therapeutic applications explore PRX antibodies for targeted cancer therapies or as biomarkers for oxidative stress-related diseases. Species-specific PRX antibodies (human, mouse, rat) facilitate cross-disciplinary studies, though challenges remain in isoform specificity due to structural similarities. Ongoing research continues to unravel PRX roles in disease mechanisms and their potential as diagnostic or therapeutic targets.

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