| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MCF2L2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下为基于学术文献结构模拟的3篇关于MCF2L2抗体的参考文献示例(注：具体文献需通过学术数据库验证)：
1. **标题**：MCF2L2 regulates cancer cell invasion through RhoA signaling pathway
**作者**：Zhang Y, et al.
**摘要**：研究利用特异性MCF2L2抗体发现该蛋白通过激活RhoA信号通路增强乳腺癌细胞侵袭能力，为癌症转移机制提供新靶点。
2. **标题**：Development of a novel monoclonal antibody for detecting MCF2L2 in glioblastoma tissues
**作者**：Kim S, et al.
**摘要**：团队开发了高特异性抗MCF2L2单克隆抗体，验证其在胶质瘤组织中的高表达，提示其可作为神经肿瘤诊断潜在标志物。
3. **标题**：MCF2L2 antibody-based therapeutic inhibits lung metastasis in vivo
**作者**：Wang H, et al.
**摘要**：研究采用人源化MCF2L2抗体进行动物实验，证实其通过阻断细胞迁移信号显著抑制肺癌小鼠模型转移，具有临床转化潜力。
**说明**：以上为模拟文献示例，实际文献请通过PubMed/Google Scholar以"MCF2L2 antibody"+"具体研究领域"为关键词检索。建议优先选择近5年发表的论文并关注抗体应用场景(如Western blot、IHC等实验方法)。
The MCF2L2 antibody targets the MCF2-like protein 2 (MCF2L2), a guanine nucleotide exchange factor (GEF) encoded by the *MCF2L2* gene. MCF2L2 regulates Rho GTPases, particularly Rac1 and Cdc42. which are critical for cytoskeletal dynamics, cell motility, and intracellular signaling. This protein contains a Dbl homology (DH) domain responsible for GEF activity and a pleckstrin homology (PH) domain involved in membrane targeting. MCF2L2 is implicated in neuronal development, cancer progression, and other cellular processes linked to Rho GTPase signaling dysregulation.
Antibodies against MCF2L2 are essential tools for studying its expression, localization, and function in vitro and in vivo. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate MCF2L2's role in diseases such as cancer, where aberrant Rho signaling may drive metastasis, or neurodevelopmental disorders. Commercial MCF2L2 antibodies are typically raised in hosts like rabbits or mice, with validation across specific applications. Researchers rely on these antibodies to explore MCF2L2's interactions with signaling pathways, its regulatory mechanisms, and potential therapeutic targeting. However, batch variability and specificity challenges necessitate careful validation using knockout controls or siRNA-based approaches to ensure accurate experimental outcomes.
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