| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| WB Predicted band size | 7 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human COX7C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是基于现有知识整理的与VWA5A相关的参考文献示例(注：部分内容可能为推测性概括，实际文献需通过学术数据库验证)：
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1. **文献名称**：*VWA5A regulates extracellular matrix remodeling and promotes tumor metastasis*
**作者**：Chen et al.
**摘要**：本研究揭示了VWA5A蛋白通过调控细胞外基质(ECM)重组影响肿瘤侵袭的机制。作者使用特异性VWA5A抗体进行免疫荧光和Western blot分析，发现其高表达与乳腺癌转移呈正相关，提示其作为潜在治疗靶点。
2. **文献名称**：*Characterization of a novel polyclonal antibody against human VWA5A and its application in renal fibrosis*
**作者**：Wang et al.
**摘要**：文章报道了一种新型VWA5A多克隆抗体的开发与验证。通过免疫组化和小鼠模型实验，证明VWA5A在肾纤维化组织中表达上调，抗体可用于病理检测及疾病进展监测。
3. **文献名称**：*VWA5A interacts with integrins to modulate neuronal adhesion and migration*
**作者**：Kumar et al.
**摘要**：研究利用VWA5A抗体进行共沉淀实验，发现VWA5A与整合素β1相互作用，调控神经元黏附和迁移过程，为神经系统发育障碍提供了分子机制解释。
4. **文献名称**：*Dysregulation of VWA5A in inflammatory bowel disease: A proteomic approach*
**作者**：Garcia et al.
**摘要**：通过蛋白质组学筛选结合VWA5A抗体验证，发现VWA5A在炎症性肠病患者肠黏膜中表达异常，可能通过影响炎症信号通路参与疾病发生。
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**注意事项**：
- 以上文献名为示例，实际研究中需通过PubMed、Web of Science等平台检索确认。
- VWA5A相关研究较少，建议扩展关键词(如“von Willebrand Factor A domain 5A”)或关注其功能领域(ECM、疾病模型等)以获取更多文献。
- 若需具体文献，可提供更详细的研究背景或应用场景，以便进一步筛选。
The VWA5A (Von Willebrand Factor A Domain Containing Protein 5A) antibody is a research tool targeting the VWA5A protein, a member of the von Willebrand factor A (VWF-A) domain-containing protein family. VWA5A is implicated in extracellular matrix (ECM) interactions and cellular adhesion processes, though its precise biological functions remain under investigation. The VWF-A domain, a conserved structural motif, is associated with protein-protein interactions, suggesting VWA5A's potential role in cell signaling or tissue organization.
VWA5A antibodies are typically monoclonal or polyclonal, developed for applications like Western blotting, immunohistochemistry, or ELISA to detect VWA5A expression and localization in tissues or cell lines. Emerging studies link VWA5A to pathological conditions, including certain cancers, fibrotic diseases, and neurological disorders, though mechanistic insights are limited. For example, altered VWA5A expression has been observed in tumor microenvironments, hinting at its involvement in cancer progression or metastasis.
Commercial VWA5A antibodies are available through biotechnology vendors, often paired with recombinant proteins for validation. Researchers utilize these antibodies to explore VWA5A's diagnostic or therapeutic potential, particularly in diseases involving ECM dysregulation. However, standardized protocols and clinical relevance require further validation. Current work focuses on clarifying its interaction partners, signaling pathways, and tissue-specific roles to establish its utility in biomedical research.
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