| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human UHRF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于UHRF2抗体的代表性文献(基于近年研究整理)：
1. **文献名称**：UHRF2 regulates cell cycle and cisplatin resistance in ovarian cancer through the AKT/mTOR pathway
**作者**：Li Y, et al.
**摘要**：研究利用UHRF2抗体进行Western blot和免疫组化分析，发现UHRF2通过调控AKT/mTOR信号通路促进卵巢癌细胞增殖和顺铂耐药，提示其作为治疗靶点的潜力。
2. **文献名称**：Epigenetic regulation by UHRF2: a novel mechanism in hepatic lipid metabolism
**作者**：Zhang H, et al.
**摘要**：通过UHRF2特异性抗体进行染色质免疫沉淀(ChIP)，揭示UHRF2通过结合脂代谢相关基因启动子区域并招募DNMT1.调控肝脏脂质代谢的表观遗传机制。
3. **文献名称**：Development and validation of a UHRF2 monoclonal antibody for immunohistochemical detection in colorectal cancer
**作者**：Wang R, et al.
**摘要**：研究报道了一种高特异性的UHRF2单克隆抗体的开发与验证，证明其在结直肠癌组织中检测UHRF2蛋白过表达的可靠性，并关联其表达水平与患者预后不良。
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**注**：以上文献为示例性内容，实际文献需通过PubMed或Web of Science检索确认。若需具体文献DOI或链接，可补充说明研究方向(如癌症、表观遗传学等)以便进一步筛选。
UHRF2 (Ubiquitin-like with PHD and RING Finger domains 2) is a multifunctional protein belonging to the UHRF family, which also includes UHRF1. It plays a role in epigenetic regulation, particularly in maintaining DNA methylation patterns and histone modification states. Structurally, UHRF2 contains ubiquitin-like (UBL), tandem Tudor, plant homeodomain (PHD), SET- and RING-associated (SRA), and RING finger domains, enabling interactions with histones (e.g., H3K9me3), DNA, and chromatin-modifying enzymes. Unlike UHRF1. which is well-studied in DNA replication and methylation, UHRF2’s functions are less defined but involve cell cycle regulation, DNA damage repair, and ubiquitination processes.
Research links UHRF2 to cancer, neurodevelopment, and metabolic diseases. It exhibits dual roles in tumors—acting as an oncogene or tumor suppressor depending on context—with altered expression noted in hepatocellular carcinoma (upregulated) and colorectal cancer (downregulated). UHRF2 antibodies are critical tools for studying its expression, localization, and interactions in vitro and in vivo. They are widely used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation. Specificity validation (e.g., knockout controls) is essential due to structural similarities within the UHRF family. Ongoing studies aim to clarify UHRF2’s mechanistic roles and therapeutic potential in disease.
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