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Mouse Monoclonal TRIM31 Antibody

  • 中文名： TRIM31抗体
  • 别    名： nan
货号: IPDX15458
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TRIM31
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于TRIM31抗体的3篇参考文献示例(注：内容为模拟概括，非真实文献)：

1. **文献名称**：TRIM31 promotes hepatocellular carcinoma progression by stabilizing c-Myc protein through ubiquitination modification

**作者**：Li Y, Chen J, Wang H

**摘要**：该研究利用TRIM31抗体进行免疫印迹和免疫组化分析，发现TRIM31在肝癌组织中高表达，并通过泛素化修饰调控c-Myc蛋白稳定性，促进肿瘤细胞增殖和转移。

2. **文献名称**：TRIM31 negatively regulates NF-κB signaling by targeting TAB2/3 for degradation in inflammatory responses

**作者**：Zhang L, Liu X, Wei R

**摘要**：通过TRIM31抗体检测其在巨噬细胞中的表达，研究发现TRIM31通过降解TAB2/3蛋白抑制NF-κB信号通路活化，从而在炎症反应中发挥负调控作用。

3. **文献名称**：High expression of TRIM31 correlates with poor prognosis and immune infiltration in gastric cancer

**作者**：Wang Q, Zhou T, Xu M

**摘要**：使用TRIM31抗体对胃癌组织进行免疫组化染色，发现TRIM31高表达与患者生存率低相关，其可能通过调节肿瘤微环境中免疫细胞浸润促进胃癌进展。

(注：以上文献信息为示例性内容，实际研究中需以真实数据库检索结果为准。)

背景信息

TRIM31 (Tripartite Motif-containing Protein 31) is a member of the TRIM family of proteins, which are characterized by a conserved tripartite motif comprising RING, B-box, and coiled-coil domains. These proteins play diverse roles in cellular processes, including innate immunity, apoptosis, and antiviral defense. TRIM31. specifically, is known to function as an E3 ubiquitin ligase, mediating post-translational modifications that regulate protein stability and interactions. It has been implicated in modulating inflammatory signaling pathways, such as NF-κB and MAPK, and is involved in cellular responses to pathogens and stress. Recent studies highlight its dual roles in cancer, acting as either an oncogene or tumor suppressor depending on the context. For example, TRIM31 overexpression is linked to gastric cancer progression, while its downregulation is associated with hepatocellular carcinoma. TRIM31 antibodies are essential tools for investigating these mechanisms, enabling detection and quantification of TRIM31 expression in tissues or cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers also use these antibodies to explore TRIM31’s interaction partners and its role in ubiquitination-dependent pathways. Additionally, TRIM31’s involvement in mitochondrial function, including regulation of reactive oxygen species (ROS) and mitophagy, has spurred interest in its potential as a therapeutic target. The development and validation of high-specificity TRIM31 antibodies thus contribute significantly to understanding its physiological and pathological functions, offering insights into disease mechanisms and therapeutic strategies.

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