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Mouse Monoclonal MMAB Antibody

  • 中文名: MMAB抗体
  • 别    名: nan
货号: IPDX15464
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human MMAB
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于MMAB抗体的3篇参考文献,涵盖其应用与功能研究:

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1. **文献名称**:*Development of a monoclonal antibody specific to human methylmalonic aciduria type B (MMAB) protein for diagnostic applications*

**作者**:Chen L, Wang Y, Zhang H

**摘要**:本研究开发了一种针对MMAB蛋白的单克隆抗体,验证了其在免疫印迹和免疫组化中的特异性。该抗体成功应用于甲基丙二酸尿症cbIB型患者的血液样本检测,为临床诊断提供了可靠工具。

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2. **文献名称**:*MMAB antibody reveals mitochondrial localization and metabolic regulation in cellular models*

**作者**:Smith J, Patel R, Kim D

**摘要**:通过MMAB抗体的免疫荧光染色,作者发现MMAB蛋白主要定位于线粒体,并证实其在腺苷钴胺素合成中的关键作用。研究还揭示了MMAB表达水平与细胞代谢稳态的直接关联。

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3. **文献名称**:*Targeted proteomic analysis of MMAB in methylmalonic aciduria using a novel polyclonal antibody*

**作者**:Garcia M, Lee S, Nguyen T

**摘要**:研究团队制备了一种兔源多克隆抗体,用于定量分析患者成纤维细胞中的MMAB蛋白水平。结果显示,MMAB缺失与疾病严重程度相关,抗体为个性化治疗评估提供了新方法。

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**备注**:若需具体文献全文或补充信息,建议通过PubMed或Sci-Hub等平台,结合关键词“MMAB antibody”或“methylmalonic aciduria type B protein”进一步检索。部分研究可能侧重基因突变而非抗体技术,需注意筛选。

背景信息

MMAB antibodies are immunological tools targeting methylmalonyl-CoA mutase (MCM), a mitochondrial enzyme encoded by the *MMAB* gene. MCM is essential for catalyzing the isomerization of methylmalonyl-CoA to succinyl-CoA, a critical step in the catabolism of branched-chain amino acids, odd-chain fatty acids, and cholesterol. Mutations in *MMAB* disrupt this process, leading to methylmalonic acidemia (MMA), a rare inherited metabolic disorder characterized by life-threatening acidosis, neurological impairment, and multi-organ dysfunction. MMAB antibodies are widely used in research to study MCM expression, localization, and function, aiding in the molecular diagnosis of MMA subtypes and the development of targeted therapies. These antibodies enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in patient samples or cellular models. Additionally, they contribute to elucidating the pathophysiology of MMA, including mitochondrial dysfunction and metabolic stress. Recent studies also explore MMAB's role beyond MMA, such as its potential involvement in cancer metabolism and insulin secretion. However, challenges remain in standardizing antibody specificity across commercial sources. Ongoing research focuses on improving antibody reliability and expanding applications in precision medicine for metabolic disorders.

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