首页 / 产品 / 抗体 / 一抗

Mouse Monoclonal DTX3L Antibody

  • 中文名: DTX3L抗体
  • 别    名: nan
货号: IPDX15461
Price: ¥1280
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/100-1/200 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human DTX3L
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

参考文献

以下是3-4条关于DTX3L抗体的虚构参考文献示例(基于领域内常见研究主题,实际文献需通过学术数据库核实):

---

1. **文献名称**: *DTX3L regulates antiviral innate immunity by targeting IRF7 for ubiquitination*

**作者**: Jostinsdottir T, et al.

**摘要**: 本研究通过免疫共沉淀(IP)和Western blot技术,利用DTX3L特异性抗体揭示了DTX3L在抗病毒天然免疫中的作用。研究表明,DTX3L作为E3泛素连接酶复合物的一部分,可泛素化修饰IRF7蛋白并调控I型干扰素通路。抗体特异性通过DTX3L敲除细胞系验证。

2. **文献名称**: *The interaction between DTX3L and ARF4 in protein trafficking pathways*

**作者**: Zhang Y, et al.

**摘要**: 本文利用DTX3L单克隆抗体进行免疫荧光染色和共聚焦显微镜分析,证实DTX3L与ADP-核糖基化因子ARF4在细胞内膜运输中的相互作用。研究提示DTX3L可能通过泛素化调控ARF4相关囊泡运输复合体的稳定性。

3. **文献名称**: *DTX3L antibody-based immunohistochemical analysis in head and neck squamous cell carcinoma*

**作者**: Takagi S, et al.

**摘要**: 通过商业化DTX3L多克隆抗体对头颈鳞癌组织进行免疫组化(IHC)分析,发现DTX3L蛋白在肿瘤组织中的高表达与患者预后不良相关。抗体特异性通过siRNA敲低实验及质谱结果交叉验证。

4. **文献名称**: *DTX3L modulates Notch signaling through interaction with Deltex1 in neural development*

**作者**: Yang L, et al.

**摘要**: 研究采用DTX3L抗体进行免疫沉淀-质谱联用(IP-MS),鉴定出DTX3L与Deltex1在神经发育中的协同作用。Western blot和ChIP实验表明,DTX3L通过调控Notch信号通路靶基因的泛素化水平影响神经干细胞分化。

---

**注意**:以上为模拟文献,实际研究中请通过PubMed、Web of Science等平台检索具体文献(关键词:DTX3L antibody, DTX3L ubiquitin ligase, DTX3L immune response)。若需真实文献,建议补充研究背景或具体应用场景(如疾病模型、实验方法)。

背景信息

The DTX3L (Deltex 3-like) antibody is a research tool targeting the DTX3L protein, a member of the Deltex family of E3 ubiquitin ligases. DTX3L plays a critical role in ubiquitination-mediated signaling pathways, particularly in modulating immune responses and cellular homeostasis. It forms a complex with PARP9 and PARP14. linking ubiquitination and ADP-ribosylation processes. This interaction is implicated in DNA repair, inflammation, and interferon signaling, highlighting its regulatory role in innate immunity and cancer biology. DTX3L also participates in B-cell receptor signaling and lymphocyte development. Antibodies against DTX3L are widely used to study its expression, localization, and function in diseases such as lymphoma, autoimmune disorders, and viral infections. Recent studies suggest its involvement in chromatin remodeling and antiviral defense, making it a potential therapeutic target. Researchers employ DTX3L antibodies in techniques like Western blot, immunofluorescence, and co-immunoprecipitation to explore its molecular partnerships and mechanistic contributions to cellular pathways. Its dual role in ubiquitination and PARP-mediated processes underscores its importance in bridging post-translational modifications with disease pathogenesis.

客户数据及评论

折叠内容

大包装询价

×