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Mouse Monoclonal HECTD2 Antibody

  • 中文名: HECTD2抗体
  • 别    名: nan
货号: IPDX15443
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human HECTD2
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于HECTD2抗体的3篇示例参考文献(注:以下内容为虚构示例,实际文献需通过学术数据库检索确认):

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1. **文献名称**: "HECTD2 regulates Wnt/β-catenin signaling through ubiquitination of Dishevelled in colorectal cancer"

**作者**: Li X, et al.

**摘要**: 本研究利用HECTD2特异性抗体,揭示了HECTD2通过泛素化修饰Dishevelled蛋白调控Wnt/β-catenin信号通路,促进结直肠癌进展的机制。实验表明,HECTD2抗体在免疫共沉淀和Western blot中有效检测其相互作用及表达水平。

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2. **文献名称**: "The role of HECTD2 in neuronal protein aggregation and Parkinson's disease pathogenesis"

**作者**: Smith J, et al.

**摘要**: 通过免疫组化和免疫荧光技术结合HECTD2抗体,研究发现HECTD2在帕金森病患者脑组织中异常表达,并参与α-synuclein蛋白的泛素化降解,提示其作为神经退行性疾病治疗靶点的潜力。

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3. **文献名称**: "Development and validation of a novel monoclonal antibody against human HECTD2 for functional studies"

**作者**: Wang Y, et al.

**摘要**: 本文报道了一种高特异性HECTD2单克隆抗体的开发与验证,通过ELISA、流式细胞术和免疫印迹证实其灵敏度及特异性,为HECTD2在细胞周期调控中的功能研究提供了可靠工具。

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如需真实文献,建议通过PubMed或Google Scholar搜索关键词(如"HECTD2 antibody" + "function"/"cancer"/"ubiquitination"),并筛选近5年研究。

背景信息

The HECTD2 antibody is a research tool designed to detect and study the HECT domain-containing E3 ubiquitin-protein ligase 2 (HECTD2), a member of the HECT family of E3 ubiquitin ligases. HECTD2 plays a critical role in the ubiquitination process, a post-translational modification that regulates protein degradation, localization, and activity via the ubiquitin-proteasome system. This enzyme contains a conserved HECT domain responsible for catalyzing the transfer of ubiquitin to substrate proteins, marking them for proteasomal degradation or functional modulation. HECTD2 is implicated in diverse cellular processes, including protein quality control, immune response regulation, and endoplasmic reticulum-associated degradation (ERAD). Dysregulation of HECTD2 has been linked to pathological conditions such as cancer, neurodegenerative diseases, and autoimmune disorders. For instance, studies suggest its involvement in tumor progression through interactions with oncogenic or tumor-suppressive pathways. The HECTD2 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to investigate HECTD2 expression, localization, and interaction partners. Its applications extend to both basic research and translational studies, aiding in the exploration of HECTD2’s molecular mechanisms and therapeutic potential. Commercial HECTD2 antibodies are typically validated for specificity and sensitivity across human, mouse, or rat samples, enabling cross-species comparative analyses. Ongoing research aims to clarify its substrate specificity and physiological roles, positioning HECTD2 as a promising target for disease biomarker discovery or drug development.

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