Mouse Monoclonal BCL2L15 Antibody

The BCL2L15 (BCL2-like 15) antibody is a research tool used to study the BCL2L15 protein, a member of the BCL-2 family, which regulates apoptosis (programmed cell death). BCL2L15 shares structural homology with other BCL-2 family proteins, containing conserved BCL-2 homology (BH) domains critical for interactions with pro- and anti-apoptotic members. Unlike canonical anti-apoptotic proteins like BCL2 or BCL-XL, BCL2L15 has been less characterized but is implicated in modulating mitochondrial apoptosis pathways, potentially influencing cellular survival under stress. Its expression varies across tissues, with roles suggested in development, cancer, and neurological disorders. The antibody is typically developed in hosts like rabbits or mice, targeting specific epitopes for applications such as Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). Researchers use it to explore BCL2L15's expression patterns, subcellular localization, and interactions in disease models, particularly in cancers where apoptosis evasion is a hallmark. Challenges include verifying specificity due to potential cross-reactivity with other BCL-2 family members. Ongoing studies aim to clarify its physiological functions and therapeutic relevance, positioning BCL2L15 as a potential biomarker or target in apoptosis-related pathologies.