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Mouse Monoclonal BCL2L15 Antibody

  • 中文名: BCL2L15抗体
  • 别    名: nan
货号: IPDX15442
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/100-1/200 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

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参考文献

以下是关于BCL2L15抗体的3篇参考文献及其摘要概括:

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1. **文献名称**:*BCL2L15 mediates apoptosis through the mitochondrial pathway*

**作者**:Smith A, et al.

**摘要**:该研究利用BCL2L15特异性抗体,通过免疫印迹和免疫荧光技术,揭示了BCL2L15蛋白在调控线粒体依赖性细胞凋亡中的作用。研究发现,BCL2L15通过与其他Bcl-2家族成员相互作用,促进细胞色素C的释放,激活caspase级联反应。

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2. **文献名称**:*Characterization of a novel monoclonal antibody against BCL2L15 for cancer biomarker discovery*

**作者**:Li Y, et al.

**摘要**:作者开发了一种高特异性的BCL2L15单克隆抗体,并验证其在人组织样本中的表达。通过免疫组化分析,发现BCL2L15在多种肿瘤中异常高表达,提示其作为潜在癌症生物标志物的价值。

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3. **文献名称**:*BCL2L15 regulates neuronal apoptosis during development*

**作者**:Wang X, et al.

**摘要**:研究利用BCL2L15抗体在小鼠模型中检测其表达模式,发现该蛋白在神经发育过程中通过抑制过度凋亡维持神经元存活。抗体特异性验证显示其在脑组织中的高灵敏度和特异性。

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**备注**:BCL2L15相关抗体研究相对较少,上述文献为模拟示例,实际检索建议通过PubMed或Google Scholar以关键词“BCL2L15 antibody”或“BCL2L15 function”获取最新数据。部分研究可能侧重功能而非抗体应用,需结合实验目的筛选。

背景信息

The BCL2L15 (BCL2-like 15) antibody is a research tool used to study the BCL2L15 protein, a member of the BCL-2 family, which regulates apoptosis (programmed cell death). BCL2L15 shares structural homology with other BCL-2 family proteins, containing conserved BCL-2 homology (BH) domains critical for interactions with pro- and anti-apoptotic members. Unlike canonical anti-apoptotic proteins like BCL2 or BCL-XL, BCL2L15 has been less characterized but is implicated in modulating mitochondrial apoptosis pathways, potentially influencing cellular survival under stress. Its expression varies across tissues, with roles suggested in development, cancer, and neurological disorders. The antibody is typically developed in hosts like rabbits or mice, targeting specific epitopes for applications such as Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). Researchers use it to explore BCL2L15's expression patterns, subcellular localization, and interactions in disease models, particularly in cancers where apoptosis evasion is a hallmark. Challenges include verifying specificity due to potential cross-reactivity with other BCL-2 family members. Ongoing studies aim to clarify its physiological functions and therapeutic relevance, positioning BCL2L15 as a potential biomarker or target in apoptosis-related pathologies.

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