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Mouse Monoclonal SMC2(acetylK114) Antibody

  • 中文名: SMC2 (acetyl K114)抗体
  • 别    名: nan
货号: IPDX15439
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/100-1/200 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenHuman SMC2 peptide
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于SMC2 (acetyl K114)抗体的3篇代表性文献的示例(注:文献为模拟示例,实际引用请查询数据库):

1. **"Acetylation of SMC2 at K114 regulates mitotic chromosome condensation"**

*Authors: Lee et al. (2020)*

**摘要**:本研究揭示了SMC2在K114位点的乙酰化通过调控condensin复合体的染色质结合能力,影响有丝分裂中染色体凝聚的动力学。作者使用SMC2 (acetyl K114)特异性抗体进行ChIP-seq和免疫荧光,发现该修饰在细胞周期中的动态变化。

2. **"Epigenetic regulation of condensin function via SMC2 acetylation"**

*Authors: Chen et al. (2018)*

**摘要**:文章报道了组蛋白乙酰转移酶p300介导的SMC2 K114乙酰化对维持基因组稳定性的作用。通过SMC2 (acetyl K114)抗体的免疫印迹分析,发现该修饰缺失会导致染色体分离异常和DNA损伤应答缺陷。

3. **"SMC2 acetylation at lysine 114 modulates its interaction with DNA repair proteins"**

*Authors: Rodriguez et al. (2021)*

**摘要**:该研究利用SMC2 (acetyl K114)抗体进行免疫共沉淀实验,揭示了乙酰化修饰通过增强SMC2与BRCA1等修复因子的相互作用,在DNA双链断裂修复中发挥关键作用。

建议通过 **PubMed** 或 **Google Scholar** 以关键词 **"SMC2 acetylation K114 antibody"** 或 **"condensin acetylation"** 检索最新文献,以获取真实研究数据。

背景信息

The SMC2 (acetyl K114) antibody is a specialized tool used to detect the acetylation of the SMC2 protein at lysine residue 114 (K114). SMC2. a core subunit of the condensin complex, plays a critical role in chromosome condensation, organization, and segregation during mitosis and meiosis. Post-translational modifications, including acetylation, regulate its function. Acetylation at K114 is thought to modulate condensin activity, potentially influencing chromatin structure, DNA repair, or transcriptional regulation. This antibody is typically developed using synthetic peptides corresponding to the acetylated K114 epitope, enabling specific recognition in assays like Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP). Its use helps researchers study the dynamic regulation of SMC2 in cell cycle progression, genome stability, and epigenetic mechanisms. Dysregulation of SMC2 or its modifications has been linked to chromosomal instability and diseases like cancer, making this antibody valuable for exploring molecular pathways in both basic and translational research. Validation often includes knockout controls or enzymatic deacetylation treatments to confirm specificity.

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