Mouse Monoclonal SMC2(acetylK114) Antibody

The SMC2 (acetyl K114) antibody is a specialized tool used to detect the acetylation of the SMC2 protein at lysine residue 114 (K114). SMC2. a core subunit of the condensin complex, plays a critical role in chromosome condensation, organization, and segregation during mitosis and meiosis. Post-translational modifications, including acetylation, regulate its function. Acetylation at K114 is thought to modulate condensin activity, potentially influencing chromatin structure, DNA repair, or transcriptional regulation. This antibody is typically developed using synthetic peptides corresponding to the acetylated K114 epitope, enabling specific recognition in assays like Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP). Its use helps researchers study the dynamic regulation of SMC2 in cell cycle progression, genome stability, and epigenetic mechanisms. Dysregulation of SMC2 or its modifications has been linked to chromosomal instability and diseases like cancer, making this antibody valuable for exploring molecular pathways in both basic and translational research. Validation often includes knockout controls or enzymatic deacetylation treatments to confirm specificity.