| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Purified recombinant fragment of human TRIM10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是关于TRIM10抗体的虚构参考文献示例(实际文献需根据具体数据库检索)：
---
1. **文献名称**：*TRIM10 regulates erythroid differentiation via modulating GATA1 activity*
**作者**：Chen L, et al.
**摘要**：本研究利用TRIM10特异性抗体，通过免疫共沉淀和Western blot技术，揭示了TRIM10在红系分化过程中与转录因子GATA1的相互作用，表明其通过泛素化修饰调控GATA1稳定性，影响红细胞成熟。
2. **文献名称**：*Development and validation of a monoclonal antibody against human TRIM10 for diagnostic applications*
**作者**：Wang Y, et al.
**摘要**：报道了一种新型TRIM10单克隆抗体的开发，验证了其在ELISA、免疫组化中的特异性，并应用于白血病患者样本检测，发现TRIM10表达水平与疾病进展相关。
3. **文献名称**：*TRIM10 modulates innate immune responses by targeting viral RNA sensors*
**作者**：Kim S, et al.
**摘要**：通过免疫荧光和流式细胞术结合TRIM10抗体，发现TRIM10负调控RIG-I/MDA5通路，抑制Ⅰ型干扰素过度产生，为病毒感染中的免疫平衡机制提供新见解。
---
注：以上为模拟内容，实际文献需通过PubMed、Google Scholar等平台检索关键词“TRIM10 antibody”或“TRIM10 function”获取。
The TRIM10 antibody is a research tool designed to detect and study TRIM10 (Tripartite Motif-containing protein 10), a member of the TRIM family of proteins involved in diverse cellular processes, including immune regulation, antiviral defense, and ubiquitination. TRIM10. also known as hematopoietic RING finger 1 (HERF1), is primarily expressed in hematopoietic tissues and plays a role in erythroid differentiation and cell cycle regulation. Its structure includes a RING domain, B-box motifs, and a coiled-coil region, typical of TRIM proteins, which facilitate protein-protein interactions and E3 ubiquitin ligase activity.
Research on TRIM10 has linked it to hematological disorders, such as anemia and leukemia, due to its role in red blood cell maturation and apoptosis. The antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze TRIM10 expression, localization, and interactions in cellular models or patient samples. Its specificity is validated through knockdown/knockout controls to ensure accurate detection.
Recent studies also explore TRIM10's involvement in immune responses, particularly its regulatory effects on inflammatory signaling pathways. As an understudied TRIM family member, TRIM10's functional mechanisms remain an active area of investigation, with the antibody serving as a critical reagent for uncovering its biological and pathological roles. Commercial TRIM10 antibodies are typically raised in rabbits or mice, with applications spanning basic research and potential clinical diagnostics.
×
