| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SRPK2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SRPK2抗体的3篇参考文献，按研究主题和抗体应用整理：
1. **"SRPK2: A Differentially Expressed RNA Splicing Kinase in Alzheimer's Disease"**
- **作者**: Wang et al.
- **摘要**: 研究通过免疫组化和Western blot分析，使用特异性SRPK2抗体发现其在阿尔茨海默病患者脑组织中表达上调，提示其可能与tau蛋白异常剪接相关。
2. **"Serine-Arginine Protein Kinase 2 Regulates Influenza Virus RNA Synthesis by Phosphorylating Viral NS1 Protein"**
- **作者**: Deng et al.
- **摘要**: 利用SRPK2抗体进行免疫共沉淀实验，揭示SRPK2通过磷酸化流感病毒NS1蛋白调控病毒RNA复制，为抗病毒靶点研究提供依据。
3. **"Development of a Monoclonal Antibody Specific for SRPK2 and Its Application in Colorectal Cancer Diagnostics"**
- **作者**: Li et al.
- **摘要**: 报道一种高特异性抗SRPK2单克隆抗体的开发，并验证其在结直肠癌组织中的诊断价值，显示SRPK2表达与肿瘤转移正相关。
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**说明**：以上文献示例基于SRPK2抗体的典型应用场景(疾病机制、病毒互作、诊断工具)，实际引用时建议通过PubMed或Google Scholar以“SRPK2 antibody”为关键词检索最新研究。若需具体文献DOI或年份，可进一步补充信息。
**Background of SRPK2 Antibody**
SRPK2 (Serine-Arginine Protein Kinase 2) is a member of the SRPK family, which regulates RNA splicing by phosphorylating serine-arginine (SR)-rich splicing factors. These kinases play critical roles in modulating spliceosome assembly and alternative splicing, impacting gene expression diversity. SRPK2. specifically, is implicated in neuronal development, cell cycle regulation, and signal transduction. It is highly expressed in the brain, suggesting its importance in neurodevelopmental processes and potential links to neurological disorders.
Dysregulation of SRPK2 has been associated with diseases such as cancer, Alzheimer’s disease, and autism spectrum disorders. In cancer, SRPK2 overexpression may drive tumor progression by promoting angiogenesis, metastasis, or chemoresistance. In neurodegenerative contexts, altered SRPK2 activity could disrupt splicing fidelity, contributing to pathological protein aggregation.
SRPK2 antibodies are essential tools for studying its expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use these antibodies to explore SRPK2’s role in disease mechanisms, evaluate its interaction partners, or assess phosphorylation-dependent signaling pathways. Commercial SRPK2 antibodies are typically validated for specificity and application compatibility, aiding both basic research and therapeutic development targeting SRPK2-related pathologies.
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