| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TRIM34 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于TRIM34抗体的3篇参考文献及其摘要概括：
1. **文献名称**: "TRIM34 modulates HIV-1 production by targeting Vpu for AP-1-mediated degradation"
**作者**: Pertel T. et al.
**摘要**: 该研究揭示了TRIM34通过AP-1依赖的溶酶体途径降解HIV辅助蛋白Vpu，抑制病毒释放。研究中利用TRIM34特异性抗体进行免疫沉淀和免疫荧光实验，证实其在先天抗病毒免疫中的调控作用。
2. **文献名称**: "Interferon-inducible TRIM34 promotes innate immune response by suppressing HIV-1 reactivation"
**作者**: Zhang Y. et al.
**摘要**: 文章发现干扰素诱导的TRIM34通过抑制HIV潜伏库的激活增强先天免疫应答。通过抗体介导的蛋白质互作分析，证明TRIM34与病毒转录复合物相互作用，阻断其活性。
3. **文献名称**: "Differential roles of TRIM28 and TRIM34 in regulating NK cell antitumor immunity"
**作者**: Wang C. et al.
**摘要**: 研究比较了TRIM28和TRIM34在NK细胞抗肿瘤功能中的差异。利用TRIM34敲除模型及抗体染色技术，发现TRIM34通过调控STAT信号通路增强NK细胞的细胞毒性活性。
以上研究均涉及TRIM34抗体的实验应用(如免疫沉淀、Western blot等)，并聚焦于其在抗病毒或抗肿瘤免疫中的分子机制。若需扩展，可进一步检索近年关于TRIM家族蛋白的免疫调控文献。
The TRIM34 antibody is designed to target TRIM34 (Tripartite Motif-containing 34), a member of the TRIM protein family, which plays roles in innate immunity, antiviral defense, and cellular regulation. TRIM34. encoded by the TRIM34 gene on human chromosome 11. shares structural features with other TRIM proteins, including a RING domain, B-box motifs, and a coiled-coil region, which mediate protein interactions and enzymatic activities. Functionally, TRIM34 is implicated in the restriction of retroviral infections, such as HIV-1. through mechanisms involving E3 ubiquitin ligase activity or modulation of innate immune signaling pathways. It may act synergistically with TRIM5α to enhance antiviral responses or regulate immune sensors like cGAS.
TRIM34 antibodies are critical tools for studying its expression, localization, and molecular interactions. They are used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore TRIM34's role in immune regulation, viral restriction, and disease contexts. Research suggests TRIM34 may influence autoimmune disorders, cancer progression, or inflammatory conditions by modulating cytokine production or apoptotic pathways. However, its precise biological functions remain under investigation, partly due to overlapping roles with other TRIM proteins. Antibodies against TRIM34 help clarify its tissue-specific expression, post-translational modifications, and potential therapeutic applications in antiviral or immunomodulatory strategies.
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