| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Rat IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | The N-terminal fragment of mouse CHTOP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是模拟生成的关于CHTOP抗体的参考文献示例(非真实文献，仅供格式参考)：
1. **文献名称**：*CHTOP as a novel chromatin target of PRMT1 in gene regulation*
**作者**：Smith A, et al.
**摘要**：本研究揭示了CHTOP作为PRMT1的关键染色质靶点，通过免疫共沉淀(使用CHTOP特异性抗体)证实其参与精氨酸甲基化，调控胚胎干细胞分化相关基因的表达。
2. **文献名称**：*Overexpression of CHTOP in acute myeloid leukemia and its therapeutic implications*
**作者**：Li Y, et al.
**摘要**：通过Western blot和免疫组化(采用兔源CHTOP多克隆抗体)，发现CHTOP在白血病细胞中高表达，其沉默可抑制癌细胞增殖，提示其作为潜在治疗靶点。
3. **文献名称**：*CHTOP mediates DNA damage repair via interaction with ATM kinase*
**作者**：Wang X, et al.
**摘要**：利用CHTOP抗体进行免疫荧光定位，发现CHTOP在DNA损伤后被招募至断裂位点，与ATM激酶协同促进修复，敲除后导致基因组不稳定性增加。
4. **文献名称**：*Epigenetic role of CHTOP in neuronal differentiation*
**作者**：Garcia R, et al.
**摘要**：研究通过ChIP-seq(使用CHTOP单克隆抗体)证明CHTOP结合神经发育基因启动子区域，调控组蛋白修饰模式，影响小鼠皮层神经元分化进程。
**注**：以上文献为模拟生成，实际研究请通过PubMed、Google Scholar等平台检索关键词“CHTOP antibody”或“CHTOP protein function”获取。
The Chtop (Chromatin target of PRMT1) antibody is a research tool designed to detect and study the Chtop protein, a nuclear factor implicated in chromatin remodeling and transcriptional regulation. Chtop was initially identified as a binding partner of protein arginine methyltransferase 1 (PRMT1), an enzyme responsible for asymmetric dimethylation of arginine residues on histone and non-histone proteins. This interaction positions Chtop as a critical mediator of PRMT1-dependent epigenetic modifications, influencing gene expression, RNA processing, and cellular differentiation.
Chtop antibodies are commonly generated using immunogenic peptides or recombinant protein fragments, enabling applications such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). These antibodies help elucidate Chtop’s role in nuclear speckle organization, mRNA export, and its involvement in DNA damage response pathways. Studies have linked dysregulated Chtop expression to oncogenesis, particularly in hematological malignancies, where aberrant PRMT1-Chtop signaling may drive leukemogenesis.
The development of Chtop antibodies has advanced research into arginine methylation’s functional diversity, offering insights into diseases linked to epigenetic dysregulation. Their specificity and reliability remain critical for dissecting Chtop’s molecular mechanisms and therapeutic potential in cancer and developmental disorders.
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