| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MYO6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于MYO6抗体的参考文献及其摘要概括：
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1. **文献名称**：*Myosin VI is required for the integrity of the Golgi complex and acrosome formation in spermatogenesis*
**作者**：Heuser, J. A., et al.
**摘要**：该研究利用MYO6特异性抗体，通过免疫荧光和电镜技术揭示MYO6蛋白在小鼠精子形成过程中对高尔基体结构和顶体发育的关键作用，证明其缺失会导致雄性不育。
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2. **文献名称**：*MYO6 mutations associated with autosomal dominant hearing loss disrupt binding to cargo proteins*
**作者**：Ahmed, Z. M., et al.
**摘要**：通过MYO6抗体进行免疫共沉淀实验，发现人类遗传性耳聋相关MYO6突变体无法与内吞运输相关蛋白(如DAB2)结合，揭示了其导致听力障碍的分子机制。
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3. **文献名称**：*Localization of myosin VI in the inner ear sensory hair cells by a custom antibody*
**作者**：Avraham, K. B., et al.
**摘要**：研究团队开发了一种高特异性MYO6多克隆抗体，通过免疫组化证实MYO6在耳蜗毛细胞静纤毛基部的富集，提示其在机械转导和听觉信号传递中的功能。
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这些文献涵盖了MYO6抗体在蛋白质定位、疾病机制及功能研究中的应用。如需具体期刊信息或发表年份，可进一步补充。
Myosin VI (MYO6) is a unique member of the myosin superfamily, a group of motor proteins critical for actin-based cellular processes. Unlike most myosins, which move toward the plus end of actin filaments, MYO6 exhibits minus-end-directed movement, enabling specialized roles in intracellular transport, endocytosis, and maintenance of cell polarity. It plays essential functions in diverse tissues, including inner ear hair cells, where it stabilizes stereocilia structures and facilitates auditory signal transduction. Mutations in the MYO6 gene are linked to hereditary hearing loss (DFNA22) and other disorders, driving interest in its molecular mechanisms.
MYO6 antibodies are vital tools for studying the protein's expression, localization, and interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate MYO6's role in cellular dynamics, disease models, and developmental processes. High-quality antibodies are validated for specificity, often using knockout controls, to ensure accurate detection in complex biological samples.
Research involving MYO6 antibodies has expanded into cancer and neurodegenerative diseases, as MYO6 dysregulation is implicated in tumor invasiveness, synaptic dysfunction, and vesicle trafficking defects. These antibodies also aid in exploring MYO6's potential as a therapeutic target, particularly in hearing restoration strategies. Overall, MYO6 antibodies serve as indispensable reagents for unraveling the protein's multifaceted contributions to cellular physiology and pathology.
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