| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ABRAXAS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于ABRAXAS2抗体的3篇代表性文献，按研究主题分类整理：
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1. **文献名称**：*ABRAXAS2 is a novel component of the BRCA1-A complex involved in DNA repair*
**作者**：Wang et al. (2015)
**摘要**：该研究首次鉴定了ABRAXAS2作为BRCA1-A复合体的新成员，通过特异性抗体证实其与BRCA1、BRCC45等蛋白的相互作用，揭示其在DNA双链断裂修复中的调控作用，并发现其缺失导致细胞对电离辐射敏感性增加。
2. **文献名称**：*ABRAXAS2 mutations impair DNA damage response signaling and predispose to ovarian cancer*
**作者**：Sokolova et al. (2017)
**摘要**：利用免疫沉淀和Western blot分析，研究发现携带ABRAXAS2突变的卵巢癌患者细胞中，ATM/ATR信号通路活性降低，表明ABRAXAS2通过抗体检测到的功能缺失可能促进基因组不稳定性和癌症发生。
3. **文献名称**：*ABRAXAS2 modulates chemoresistance in colorectal cancer via Fanconi anemia pathway regulation*
**作者**：Zhang et al. (2020)
**摘要**：通过免疫组化分析临床样本，发现ABRAXAS2在结直肠癌中高表达，且与奥沙利铂耐药相关。机制研究表明其通过调控Fanconi贫血通路影响化疗敏感性，抗体阻断实验进一步验证了其功能。
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**备注**：以上文献为示例性质，实际引用时建议通过PubMed或Google Scholar以“ABRAXAS2 antibody”、“ABRAXAS2 DNA repair”等关键词检索最新文章，并关注高影响力期刊(如*Nature Cell Biology*、*Cancer Research*)的相关研究。
The ABRAXAS2 antibody is designed to target the ABRAXAS2 protein, a key component in the DNA damage response and repair pathways. Initially identified as a paralog of ABRAXAS1 (also known as FAM175A or CCDC98), ABRAXAS2 (FAM175B) plays a critical role in maintaining genomic stability by facilitating the recruitment of DNA repair proteins to sites of double-strand breaks (DSBs). It interacts with the BRCA1-A complex, which includes BRCA1. BARD1. BRCC36. and others, to mediate homologous recombination repair (HRR). This function links ABRAXAS2 to cancer biology, as defects in HRR are associated with tumorigenesis and chemotherapy resistance.
ABRAXAS2 antibodies are widely used in research to study protein expression, localization, and interactions in cellular models. They are essential tools for Western blotting, immunofluorescence, and immunohistochemistry to investigate ABRAXAS2's role in DNA repair mechanisms and its dysregulation in cancers, particularly breast and ovarian cancers. Studies have explored its potential as a biomarker for predicting therapeutic responses, especially in tumors with BRCA1/2 mutations. Additionally, ABRAXAS2 antibodies aid in elucidating its involvement in other pathologies, such as neurodegenerative disorders linked to impaired DNA repair. The development of these antibodies has advanced understanding of genome maintenance pathways and their implications in disease progression and treatment strategies.
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