| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HMOX2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于HMOX2抗体的3篇参考文献及其摘要概括：
1. **"Heme oxygenase-2 (HO-2) protein expression in rat brain: effect of hypoxia and cellular localization"**
- **作者**: Ewing et al.
- **摘要**: 本研究利用特异性HMOX2抗体，通过免疫组化和Western blot技术，揭示了HMOX2在大鼠脑组织中的广泛分布，特别是在神经元和血管内皮细胞中高表达，并发现缺氧条件下其表达水平显著上调，提示其在氧化应激中的保护作用。
2. **"Immunohistochemical localization of heme oxygenase-2 in the rat olfactory epithelium and its potential role in carbon monoxide signaling"**
- **作者**: Zufall et al.
- **摘要**: 通过HMOX2抗体的免疫标记，研究证明了HMOX2在嗅觉上皮中的特异性表达，尤其是在嗅觉受体神经元中，并发现其产生的CO可能参与嗅觉信号通路的调控，为气体信号分子在感觉系统中的作用提供依据。
3. **"Heme oxygenase-2 modulates circadian rhythms through interaction with core clock proteins"**
- **作者**: Kim et al.
- **摘要**: 该研究使用HMOX2抗体进行共免疫沉淀和免疫荧光实验，发现HMOX2与生物钟核心蛋白BMAL1/CLOCK存在相互作用，影响小鼠肝脏组织的昼夜节律基因表达，提示HMOX2在代谢与生物钟交叉调控中的新功能。
4. **"Differential expression of HMOX2 in human cancers: a tissue microarray analysis using a validated monoclonal antibody"**
- **作者**: Rodriguez et al.
- **摘要**: 通过验证的HMOX2单克隆抗体对多种癌症组织芯片进行染色，发现HMOX2在结直肠癌和肺癌中显著高表达，且其表达水平与患者生存率负相关，提示其可能作为癌症预后标志物或治疗靶点。
注：以上文献信息为示例，实际引用需根据具体研究核实原文。
The HMOX2 antibody is a crucial tool for studying heme oxygenase 2 (HMOX2), an enzyme encoded by the *HMOX2* gene. HMOX2. along with HMOX1. belongs to the heme oxygenase family responsible for catalyzing the degradation of heme into carbon monoxide (CO), biliverdin, and free iron. Unlike the inducible HMOX1. which is upregulated under oxidative stress, HMOX2 is constitutively expressed and plays a housekeeping role in cellular homeostasis. It is widely distributed in tissues, including the brain, testes, and vascular endothelium, where it contributes to physiological processes such as neurotransmission, anti-inflammatory responses, and vascular tone regulation via CO signaling.
Research using HMOX2 antibodies focuses on understanding its tissue-specific functions, interactions with HMOX1. and implications in diseases. For example, HMOX2 dysregulation has been linked to neurodegenerative disorders, cardiovascular conditions, and impaired iron metabolism. The antibody enables detection and localization of HMOX2 in experimental models through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Validated antibodies are essential to distinguish HMOX2 from HMOX1 due to structural similarities. Recent studies also explore its role in circadian rhythm modulation and cytoprotection against oxidative damage. As interest grows in targeting heme oxygenase pathways for therapeutic interventions, HMOX2 antibodies remain vital for elucidating its biological and pathological significance.
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