| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PTGES2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3条关于PTGES2抗体的虚构参考文献示例(仅供格式参考)：
1. **"Development and characterization of a monoclonal antibody specific for human PTGES2"**
- **作者**: Tanaka A, et al.
- **摘要**: 研究团队开发了一种针对人PTGES2蛋白的单克隆抗体，通过Western blot和免疫荧光验证其特异性，证实其在检测细胞和组织内PTGES2表达中的应用价值。
2. **"PTGES2 overexpression in colorectal cancer: Implications for prognosis and therapeutic targeting"**
- **作者**: Smith JL, et al.
- **摘要**: 利用PTGES2抗体进行免疫组化分析，发现结肠癌组织中PTGES2表达显著升高，且与患者不良预后相关，提示其作为潜在治疗靶点的可能性。
3. **"Structural insights into PTGES2 function through antibody-mediated inhibition assays"**
- **作者**: Chen H, et al.
- **摘要**: 通过PTGES2特异性抗体阻断实验，揭示了PTGES2在炎症反应中的酶活性调控机制，为开发靶向抑制剂提供了实验依据。
(注：以上文献为模拟内容，实际引用需查询PubMed等数据库获取真实研究。)
**Background of PTGES2 Antibody**
Prostaglandin E synthase 2 (PTGES2) is a membrane-associated protein involved in the biosynthesis of prostaglandin E2 (PGE2), a lipid mediator critical in inflammation, fever, pain perception, and cellular proliferation. Unlike other prostaglandin synthases (e.g., PTGES1 or PTGES3), PTGES2 exhibits unique structural features, including a conserved glutathione-binding domain, and functions independently of glutathione in certain contexts. It is expressed in various tissues, with roles in both physiological homeostasis and pathological conditions, such as cancer, neurodegenerative diseases, and chronic inflammation.
PTGES2 antibodies are essential tools for studying the expression, localization, and function of PTGES2 in experimental models. These antibodies enable detection of PTGES2 via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the exploration of its regulatory mechanisms. Research using PTGES2 antibodies has revealed its involvement in modulating PGE2 levels under stress conditions, interactions with cellular membranes, and potential crosstalk with pathways like NF-κB and MAPK signaling.
Clinically, PTGES2 is investigated as a biomarker or therapeutic target, particularly in cancers where PGE2 dysregulation promotes tumor growth and immune evasion. Validated PTGES2 antibodies help dissect its contribution to disease progression, supporting drug development and diagnostic strategies. However, specificity validation remains crucial due to structural similarities among prostaglandin synthases. Overall, PTGES2 antibodies are vital for advancing mechanistic and translational studies of this enzyme in health and disease.
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