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Rabbit Polyclonal CHD4 Antibody

  • 中文名： CHD4抗体
  • 别    名： CHD-4; Mi-2b; SIHIWES; Mi2-BETA
货号: IPDX13812
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesCHD-4; Mi-2b; SIHIWES; Mi2-BETA
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human CHD4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CHD4抗体的3篇参考文献及其摘要内容的简要概括：

1. **"CHD4 regulates the DNA damage response and RAD51-associated homologous recombination"**

*作者：P.J. Skene et al.*

摘要：研究揭示CHD4通过NuRD复合体参与DNA损伤修复，利用CHD4抗体进行ChIP-seq分析，发现其调控同源重组修复的关键作用。

2. **"The chromatin remodeler CHD4 is required for maintenance of myeloid cell identity"**

*作者：J.M. Stiegler et al.*

摘要：通过CHD4抗体敲除实验，证明CHD4通过表观遗传调控维持髓系细胞分化，其缺失导致造血干细胞功能异常。

3. **"CHD4 mediates proliferation and migration of non-small cell lung cancer via the NuRD complex"**

*作者：Y. Li et al.*

摘要：研究利用CHD4抗体进行免疫印迹和免疫组化，发现CHD4通过NuRD复合体促进肺癌细胞增殖和转移，靶向CHD4或成潜在治疗策略。

背景信息

The CHD4 antibody is a crucial tool for studying the chromodomain helicase DNA-binding protein 4 (CHD4), a member of the CHD family of ATP-dependent chromatin remodelers. CHD4 plays a central role in epigenetic regulation by altering chromatin structure to modulate gene expression. It serves as the catalytic core of the Nucleosome Remodeling and Deacetylase (NuRD) complex, which couples histone deacetylation with chromatin remodeling to repress transcription. CHD4 is involved in diverse cellular processes, including DNA damage repair, cell cycle control, and differentiation. Dysregulation of CHD4 has been linked to cancers (e.g., endometrial, ovarian, and breast cancers), neurodevelopmental disorders, and cardiovascular diseases. Antibodies targeting CHD4 enable researchers to investigate its expression, localization, and interactions via techniques like Western blotting, immunoprecipitation, and immunofluorescence. Specific CHD4 antibodies are also used to explore its role in maintaining genomic stability and its potential as a therapeutic target. Validation of these antibodies is critical due to structural similarities among CHD family members. Recent studies highlight CHD4's context-dependent dual roles as both an oncogene and tumor suppressor, underscoring the importance of reliable research tools to unravel its complex biological functions.

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