| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ANM; TNT; NEM5; STNT; TNTS |
| WB Predicted band size | 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TNNT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是模拟生成的关于KLK15抗体的参考文献示例(注：实际文献需通过学术数据库查询)：
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1. **名称**: *Development of a monoclonal antibody against human KLK15 and its application in prostate cancer analysis*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种高特异性的抗人KLK15单克隆抗体，并通过Western blot和免疫组化验证其在组织样本中的反应性。结果显示，KLK15在前列腺癌组织中表达显著上调，提示其潜在作为生物标志物的价值。
2. **名称**: *KLK15 expression in ovarian cancer: Correlation with tumor progression using immunohistochemical staining*
**作者**: Zhang L, et al.
**摘要**: 通过商业化KLK15抗体对卵巢癌组织进行染色，发现KLK15高表达与晚期肿瘤分期和不良预后相关。研究支持KLK15在卵巢癌侵袭性调控中的作用。
3. **名称**: *Characterization of KLK15 enzymatic activity and its inhibition by a novel antibody-based approach*
**作者**: Müller B, et al.
**摘要**: 利用重组KLK15蛋白及特异性抗体，揭示了其丝氨酸蛋白酶活性在细胞外基质降解中的功能。开发的阻断性抗体可显著抑制肿瘤细胞迁移，为治疗干预提供新策略。
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建议通过 **PubMed** 或 **Google Scholar** 以“KLK15 antibody”、“kallikrein 15 immunohistochemistry”等关键词检索真实文献。
The KLK15 antibody is designed to target kallikrein-related peptidase 15 (KLK15), a serine protease encoded by the KLK15 gene. This enzyme is part of the human kallikrein family, comprising 15 secreted proteases (KLK1-KLK15) that play roles in tissue remodeling, hormone processing, and cancer progression. KLK15 is synthesized as an inactive zymogen, requiring proteolytic cleavage for activation. It is expressed in various tissues, including the prostate, breast, and ovaries, though its physiological functions remain less characterized compared to other kallikreins like KLK3 (PSA).
Research highlights KLK15's potential involvement in cancer, particularly hormone-related malignancies. Studies suggest KLK15 may influence signaling pathways linked to cell proliferation, angiogenesis, and metastasis. For example, elevated KLK15 expression has been observed in prostate and ovarian cancers, correlating with tumor aggressiveness or prognosis in some cohorts. However, its role appears context-dependent, with conflicting findings across cancer types.
KLK15 antibodies are primarily used as research tools to detect KLK15 protein expression in tissues or biological fluids via immunohistochemistry, Western blotting, or ELISA. These antibodies aid in elucidating KLK15's biomarker potential, therapeutic relevance, or mechanistic contributions to disease. Commercial KLK15 antibodies vary in specificity, often validated for cross-reactivity within the KLK family. Ongoing research aims to clarify its biological significance and explore clinical applications, such as targeted therapies or diagnostic assays.
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