| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CLM; LIS5 |
| WB Predicted band size | 198 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human LAMB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是几篇关于LAMB1抗体的示例参考文献(注：部分内容为虚构示例，实际文献请通过PubMed或Google Scholar检索)：
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1. **文献名称**: "LAMB1 Antibody as a Novel Biomarker for Colorectal Cancer Progression"
**作者**: Tanaka, K. et al.
**摘要**: 本研究利用LAMB1特异性抗体，通过免疫组化分析发现LAMB1在结直肠癌组织中高表达，且与肿瘤侵袭性和转移相关。抗体验证实验表明，LAMB1可能通过调控EMT(上皮-间质转化)通路促进癌细胞迁移。
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2. **文献名称**: "Characterization of a Monoclonal Antibody Targeting LAMB1 for Functional Studies in Neural Development"
**作者**: Smith, R.J. & Lee, H.
**摘要**: 报道一种新型抗LAMB1单克隆抗体的开发与验证，该抗体通过Western blot和免疫荧光确认特异性。研究显示，LAMB1在小鼠胚胎神经管发育中高表达，抗体阻断实验表明其参与神经嵴细胞的迁移调控。
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3. **文献名称**: "LAMB1 Autoantibodies in Autoimmune Encephalitis: Diagnostic and Clinical Implications"
**作者**: García-Sánchez, M. et al.
**摘要**: 首次在自身免疫性脑炎患者血清中检测到抗LAMB1自身抗体，并通过ELISA和细胞免疫染色验证。临床数据分析提示LAMB1抗体阳性患者具有独特的神经精神症状，可能成为新的诊断标志物。
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4. **文献名称**: "LAMB1 Antibody-Based Targeted Therapy in Triple-Negative Breast Cancer"
**作者**: Chen, L. et al.
**摘要**: 利用LAMB1抗体偶联药物(ADC)在三阴性乳腺癌模型中显示抗肿瘤活性。研究证实LAMB1在肿瘤血管基底膜特异性表达，抗体靶向递送化疗药物可显著抑制肿瘤生长并减少全身毒性。
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**备注**：以上文献为示例性质，实际研究请参考具体数据库。建议使用关键词“LAMB1 antibody”、“Laminin beta1”或结合疾病名称(如“LAMB1 cancer”)检索最新文献。
The LAMB1 antibody targets laminin subunit beta-1 (LAMB1), a critical component of laminins—a family of heterotrimeric glycoproteins in the extracellular matrix (ECM). Laminins, composed of α, β, and γ chains, play essential roles in cell adhesion, differentiation, and tissue organization. Specifically, LAMB1 combines with α and γ subunits (e.g., laminin-111. laminin-211) to form structural networks in basement membranes, influencing tissue integrity and cellular signaling.
LAMB1 is widely expressed in epithelial, endothelial, and neural tissues. Dysregulation of LAMB1 is linked to pathologies such as skin blistering disorders (e.g., junctional epidermolysis bullosa), cancer progression (enhanced metastasis via ECM remodeling), and kidney diseases. Antibodies against LAMB1 are vital tools for studying its expression, localization, and function in normal and diseased states. They are used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize basement membrane structures or assess LAMB1's role in cell-ECM interactions.
Research also explores LAMB1's potential as a biomarker or therapeutic target, particularly in cancers where its overexpression correlates with poor prognosis. However, challenges remain in distinguishing LAMB1-specific signals from cross-reactivity with other laminin isoforms. Validated LAMB1 antibodies are thus crucial for advancing mechanistic insights into ECM biology and associated diseases.
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