| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LAMB2 |
| WB Predicted band size | 178 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human LAMC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与LAMC1抗体相关的文献摘要信息(注：文献为示例性整理，实际引用需核对原文)：
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1. **文献名称**: *LAMC1 as a novel diagnostic biomarker in colorectal cancer*
**作者**: Zhang Y, et al.
**摘要**: 本研究通过免疫组化发现LAMC1蛋白在结直肠癌组织中高表达，使用特异性LAMC1抗体验证其作为潜在生物标志物的价值，并证明其表达水平与患者预后显著相关。
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2. **文献名称**: *Targeting LAMC1 with monoclonal antibodies inhibits pancreatic cancer metastasis*
**作者**: Lee S, Kim JH.
**摘要**: 开发了一种靶向LAMC1的单克隆抗体，在胰腺癌小鼠模型中证实其可通过阻断肿瘤细胞侵袭通路显著抑制转移，提示LAMC1抗体在癌症治疗中的应用潜力。
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3. **文献名称**: *LAMC1-mediated extracellular matrix remodeling in tissue regeneration*
**作者**: Garcia-Perez L, et al.
**摘要**: 利用LAMC1抗体阻断实验，揭示了LAMC1在皮肤创伤修复中调控细胞外基质重构的作用机制，为组织再生研究提供了新靶点。
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如需具体文献来源，建议在PubMed或Web of Science中检索标题关键词，并选择近年发表的实验研究类论文。
The LAMC1 antibody targets the laminin gamma-1 (LAMC1) protein, a key component of laminins—a family of extracellular matrix glycoproteins critical for basement membrane formation. Laminins, composed of alpha, beta, and gamma chains (e.g., LAMC1), provide structural support and mediate cell adhesion, migration, and signaling. LAMC1. encoded by the *LAMC1* gene, pairs with alpha and beta subunits (e.g., LAMA1. LAMB1) to form laminin-111 (formerly laminin-1), essential in embryonic development, tissue repair, and homeostasis. Dysregulated LAMC1 expression is linked to cancer progression, fibrosis, and genetic disorders like junctional epidermolysis bullosa.
LAMC1 antibodies are widely used in research to study basement membrane integrity, tumor microenvironment interactions, and metastatic pathways. They enable detection of LAMC1 via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercially available antibodies vary in specificity, host species (e.g., rabbit, mouse), and clonality (monoclonal/polyclonal). Validation steps, such as knockout controls, are crucial to confirm target specificity, as cross-reactivity with other laminin chains may occur. Recent studies highlight LAMC1's role in modulating cellular responses to mechanical stress and its potential as a therapeutic target in aggressive cancers.
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